| Type | Description |
|---|---|
| Definition | leucine zipper tumor suppressor 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-23 11:34:00 | Study found that LZTS2 was downregulated in nasopharyngeal carcinoma patients and predicted poor prognosis. Functionally, we showed that LZTS2 suppresses tumorigenesis and radioresistance in nasopharyngeal carcinoma in a p85-dependent manner. | 29409973 |
| 2018-09-01 11:15:00 | LZTS2 promoter hypermethylation is associated with laryngeal squamous cell carcinoma. | 29499699 |
| 2013-11-16 11:09:00 | LZTS2 could inhibit cell proliferation and cell cycle transition at the G1/S phase and was implicated in the regulation of proteins associated with the canonical Wnt pathway, including GSK3B and beta-catenin through inactivating the Akt pathway. | 23761130 |
| 2013-04-20 10:29:00 | deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development. | 23275340 |
| 2010-12-06 10:56:00 | LZTS2 is a beta-catenin-interacting protein and modulates beta-catenin signaling and localization | 17000760 |
| Type | IDs |
|---|---|
| Synonymous | LAPSER1 |
| Gene |
UniProtKB-ID:
LZTS2_HUMAN,
B4DP66_HUMAN
UniprotKB:
Q9BRK4,
B4DP66
UniParc:
UPI00001BD944,
UPI00017A77E1
EMBL:
BC006212,
AK298208,
AB058716,
CH471066,
AY029201,
BC058938,
AL834338,
AL133215
Ensembl:
ENSG00000107816
KO:
hsa:84445
|
| Nucleutide sequences |
EMBL-CDS:
BAB47442.1,
EAW49791.1,
CAD39005.1,
EAW49792.1,
AAK31577.1,
AAH58938.1,
EAW49790.1,
AAH06212.2,
BAG60478.1
Ensembl_TRS:
ENST00000370220,
ENST00000370223
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000359240,
ENSP00000359243
RefSeq:
NP_001305028.1,
XP_016872270.1,
NP_001305029.1,
NP_001305030.1,
XP_005270279.1,
NP_115805.1
|
| Others |
UniRef100:
UniRef100_B4DP66,
UniRef100_Q9BRK4
UniRef90:
UniRef90_Q9BRK4,
UniRef90_B4DP66
UniRef50:
UniRef50_Q9BRK4
UniGene:
Hs.523221,
Hs.734981
CCDS:
CCDS7507.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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