| Type | Description |
|---|---|
| Definition | PAS domain containing serine/threonine kinase |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 10:38:00 | MTORC1-PASK signaling is required for the rise of myogenin-positive committed myoblasts. | 31072927 |
| 2019-12-07 12:40:00 | we show that the nuclear PASK associates with the mammalian H3K4 MLL2 methyltransferase complex and enhances H3K4 di- and tri-methylation. We also show that PASK is a histone kinase that phosphorylates H3 at T3, T6, S10 and T11. | 31529049 |
| 2019-05-04 10:22:00 | we provide the first evidence for a role of USF1 in respiration since it appeared to complement Cbf1 in vivo as determined by respiration phenotypes. In addition, we confirmed USF1 as a substrate of human PAS kinase (hPASK) in vitro Combined, our data supports a model in which Cbf1/USF1 functions to partition glucose toward respiration and away from lipid biogenesis | 30381292 |
| 2013-11-16 10:04:00 | PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated PDX-1 protein degradation in pancreatic beta-cells. | 23853095 |
| 2013-10-19 10:04:00 | Mutations that affect PAS domain cause a severe protein trafficking defect and change the interactions with Kv11.1 channels. | 23721480 |
| Type | IDs |
|---|---|
| Synonymous | PASKIN, STK37 |
| Gene |
UniProtKB-ID:
PASK_HUMAN,
B7Z7V7_HUMAN,
B7Z7R6_HUMAN
UniprotKB:
Q96RG2,
B7Z7V7,
B7Z7R6
UniParc:
UPI000013C995,
UPI0001915295,
UPI0000EE3905,
UPI00019151C6,
UPI0000456F4C
EMBL:
AC005237,
AK302417,
U79240,
D50925,
CH471063,
CR749231,
AK302561,
BC043495,
BC063585,
AF387103,
BC050565
Ensembl:
ENSG00000115687
KO:
hsa:23178
|
| Nucleutide sequences |
EMBL-CDS:
AAK69752.1,
AAH43495.1,
BAA09484.2,
AAB50198.1,
CAH18087.1,
AAH50565.1,
AAH63585.1,
EAW71238.1,
BAH13743.1,
BAH13702.1
Ensembl_TRS:
ENST00000234040,
ENST00000358649,
ENST00000544142,
ENST00000405260,
ENST00000403638
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000234040,
ENSP00000441374,
ENSP00000351475,
ENSP00000384438,
ENSP00000384016
RefSeq:
XP_016859125.1,
NP_001239051.1,
NP_001239049.1,
XP_016859124.1,
XP_005247048.1,
XP_011509132.1,
XP_011509136.1,
XP_011509135.1,
NP_001239048.1,
XP_011509134.1,
XP_011509137.1,
NP_001239053.1,
XP_011509133.1,
XP_011509130.1,
NP_055963.2,
XP_011509131.1
|
| Others |
UniRef100:
UniRef100_B7Z7R6,
UniRef100_Q96RG2
UniRef90:
UniRef90_Q96RG2
UniRef50:
UniRef50_Q96RG2
UniGene:
Hs.397891
CCDS:
CCDS58758.1,
CCDS58759.1,
CCDS2545.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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