| Type | Description |
|---|---|
| Definition | La ribonucleoprotein domain family member 7 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 11:44:00 | functios as a bridging factor for snoRNA-guided modification of the U6 snRNA and alterations in splicing fidelity contribute to the etiology of the Alazami syndrome. | 32017898 |
| 2018-09-29 10:16:00 | may have inhibited the proliferation and increased the radioiodine uptake of PTC cells by regulating the SHH signaling pathway. | 29620212 |
| 2018-09-15 10:05:00 | a structural model for Larp7 binding to the 7SK 3' end and mechanism for 7SK RNP assembly. This work provides insight into how this domain contributes to 7SK recognition and assembly of the core 7SK RNP. | 29946027 |
| 2017-09-02 10:21:00 | knockdown induces progressive time-dependent telomere shortening concomitant with a reduction in telomerase enzymatic activity and a decrease in full-length (catalytically active) TERT mRNA in vitro, and that humans with Lduanyu377 deficiency display dramatically short telomeres, borderline anemia in younger generations, and anticipation consistent with a telomeropathy. | 27766953 |
| 2017-07-01 11:47:00 | The 7SK small nuclear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, also functions as a canonical transcription factor that, in collaboration with the little elongation complex (LEC) comprising ELL, Ice1, Ice2, and ZC3H8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) genes. | 28254838 |
| Type | IDs |
|---|---|
| Synonymous | ALAZS, HDCMA18P, PIP7S |
| Gene |
UniProtKB-ID:
LARP7_HUMAN
UniprotKB:
Q4G0J3
UniParc:
UPI000020B34C,
UPI0000141279,
UPI000020B343
EMBL:
BC107709,
EU667388,
BC066945,
AL049996,
CH471057,
AC106864,
AF068284
Ensembl:
ENSG00000174720
KO:
hsa:51574
|
| Nucleutide sequences |
EMBL-CDS:
ACD13786.1,
AAI07710.2,
AAH66945.1,
CAB43230.1,
AAF65503.1,
EAX06284.1
Gene_ORFName:
HDCMA18P
Ensembl_TRS:
ENST00000651579,
ENST00000324052,
ENST00000509061,
ENST00000344442
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000499190,
ENSP00000344950,
ENSP00000422626,
ENSP00000314311
RefSeq:
XP_024309855.1,
NP_057732.2,
NP_001357908.1,
NP_001357906.1,
XP_024309851.1,
NP_001357909.1,
NP_001357911.1,
XP_024309850.1,
XP_024309852.1,
XP_024309854.1,
NP_001253968.1,
NP_001357907.1,
NP_056269.1,
NP_001357910.1,
NP_001357903.1,
NP_001357905.1,
XP_024309857.1,
NP_001357904.1
|
| Others |
UniRef100:
UniRef100_Q4G0J3
UniRef90:
UniRef90_Q4G0J3
UniRef50:
UniRef50_Q4G0J3
UniGene:
Hs.713663
CCDS:
CCDS58924.1,
CCDS3701.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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