| Type | Description |
|---|---|
| Definition | glucocorticoid induced 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 10:10:00 | GLCCI1 is a downstream molecule of the GC-GR cascade that acts as an antiapoptotic mediator in thymic T cells. Phosphorylated GLCCI1colocalized with microtubules in transfected cells. GR-dependent upregulation of GLCCI1 was proapoptotic in a cultured thymocyte cell line. Transgenic mice overexpressing human GLCCI1 had enlarged thymi with many thymocytes. GLCCI1 bound to both LC8 and PAK1. It reduced BIM expression. | 30860871 |
| 2019-09-14 11:18:00 | this study found the GG genotype of GLCCI1 to be associated with better inhaled corticosteroids treatment response in asthma patients | 29345236 |
| 2019-08-10 11:09:00 | The rs37973 polymorphism of GLCCI1 is related to postoperative recovery from chronic rhinosinusitis (CRS) for individual sensitivity to glucocorticoids. Furthermore, AA genotype was associated with better treatment response in CRS. | 30256538 |
| 2019-04-06 12:40:00 | GLCCI1 variant was associated with a significant decrease of the total lung capacity at 3 years after lung transplantation | 30229311 |
| 2018-10-27 10:49:00 | The GLCCI1 rs37973 variant is a risk factor for glucocorticoid resistance in Chinese patients with SAR who receive short-term intranasal corticosteroids treatment. one genotype of GLCCI1, rs37973, was significantly associated with the INCS response. The effective rate of the GG group was lower than those of the AA and AG groups (AA vs. GG: 73.7% vs. 51.6%, P=0.007; AG vs. GG: 78.8% vs. 51.6%, P=0.000). | 29981236 |
| Type | IDs |
|---|---|
| Synonymous | FAM117C, GCTR, GIG18, TSSN1 |
| Gene |
UniProtKB-ID:
GLCI1_HUMAN
UniprotKB:
Q86VQ1
UniParc:
UPI00001907F7
EMBL:
CH471073,
BC011254,
BC050291,
CH236948
Ensembl:
ENSG00000106415
KO:
hsa:113263
|
| Nucleutide sequences |
EMBL-CDS:
AAH11254.1,
EAL24302.1,
AAH50291.1,
EAW93607.1
Ensembl_TRS:
ENST00000223145
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000223145
RefSeq:
NP_612435.1
|
| Others |
UniRef100:
UniRef100_Q86VQ1
UniRef90:
UniRef90_Q86VQ1
UniRef50:
UniRef50_Q86VQ1
UniGene:
Hs.131673
CCDS:
CCDS34601.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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