| Type | Description |
|---|---|
| Definition | cyclin dependent kinase inhibitor 2C |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:07:00 | MCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation. | 32111816 |
| 2020-08-22 15:28:00 | A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor. | 32483149 |
| 2019-10-05 10:22:00 | an oncogenic role for the protein lysine methyltransferase SETDB2 in leukemia pathogenesis. It is overexpressed in pre-BCR(+) ALL and required for their maintenance in vitro and in vivo. SETDB2 expression is maintained as a direct target gene of the chimeric transcription factor E2A-PBX1 in a subset of ALL and suppresses expression of the cell-cycle inhibitor CDKN2C through histone H3K9 tri-methylation. | 29694893 |
| 2018-09-29 11:24:00 | Low P18 expression is associated with multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors. | 29134609 |
| 2018-02-24 11:12:00 | Cycling hypoxia could induce significant changes in CLDN1 and CLDN7 expression in nasopharyngeal cancer cells, indirectly regulation P18 expression and affecting cell invasion/proliferation. | 28055967 |
| Type | IDs |
|---|---|
| Synonymous | INK4C, p18, p18-INK4C |
| Gene |
UniProtKB-ID:
CDN2C_HUMAN,
Q6ICV4_HUMAN
UniprotKB:
P42773,
Q6ICV4
UniParc:
UPI0000047FD9
EMBL:
AK091170,
CH471059,
CR450289,
BC016173,
AF041249,
BC005041,
AY094608,
AF041250,
U17074,
AF041248,
BC000598
Ensembl:
ENSG00000123080
KO:
hsa:1031
|
| Nucleutide sequences |
EMBL-CDS:
AAM11873.1,
AAH16173.1,
AAC39782.1,
AAC50074.1,
AAH05041.1,
AAH00598.1,
AAC39783.1,
EAX06834.1,
EAX06836.1,
CAG29285.1,
EAX06833.1,
BAG52297.1
Gene_ORFName:
hCG_40289
Ensembl_TRS:
ENST00000396148,
ENST00000262662,
ENST00000371761
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000379452,
ENSP00000262662,
ENSP00000360826
RefSeq:
NP_001253.1,
NP_523240.1
|
| Others |
UniRef100:
UniRef100_P42773
UniRef90:
UniRef90_P42773
UniRef50:
UniRef50_P42773
UniGene:
Hs.525324
CCDS:
CCDS555.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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