| Type | Description |
|---|---|
| Definition | GSK3B interacting protein |
| Date | Results | Publications |
|---|---|---|
| 2018-12-22 10:12:00 | Findings support the idea that in addition to its reported role in modulating Drp1, Ser637 phosphorylation causing mitochondrial elongation, GSKIP acts as a scavenger to take GSK3beta away from the beta-catenin destruction complex or as a competitor for GSK3beta binding in the Wnt pathway. | 29694914 |
| 2017-05-20 14:20:00 | findings highlight an essential compartmentalization of both and GSK3beta by GSKIP, and ascribe a function to a cytosolic interaction as a regulatory factor in the control of canonical Wnt signaling. | 27484798 |
| 2016-01-02 11:57:00 | demonstrate that overexpression of ATG2B and GSKIP enhances hematopoietic progenitor differentiation, including of megakaryocytes, by increasing progenitor sensitivity to thrombopoietin | 26280900 |
| 2011-06-18 11:08:00 | analysis of the GSK3beta-GSKIPtide complex structure and the X-ray crystal structures of GSK3beta-FRATide and GSK3beta-AxinGID complexes suggests that the hydroxyl group of Y288 is crucial to maintaining a hydrogen bond network in GSK3beta-FRATide | 21328310 |
| 2010-01-21 00:00:00 | GSKIP is a naturally occurring protein that is homologous with the GSK3beta interaction domain of Axin and is able to negatively regulate GSK3beta of the Wnt signaling pathway. | 16981698 |
| Type | IDs |
|---|---|
| Synonymous | C14orf129, HSPC210 |
| Gene |
UniProtKB-ID:
GSKIP_HUMAN,
A0A024R6P6_HUMAN
UniprotKB:
Q9P0R6,
A0A024R6P6
UniParc:
UPI0000034E26
EMBL:
AF151044,
AK094654,
AL359240,
BC004818,
AK000796,
CH471061
Ensembl:
ENSG00000100744
KO:
hsa:51527
|
| Nucleutide sequences |
EMBL-CDS:
EAW81634.1,
BAG52902.1,
BAA91380.1,
AAF36130.1,
AAH04818.1,
EAW81635.1
Gene_ORFName:
HSPC210,
hCG_24517
Ensembl_TRS:
ENST00000554182,
ENST00000556095,
ENST00000555181,
ENST00000438650
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000450420,
ENSP00000451188,
ENSP00000412315,
ENSP00000451384
RefSeq:
NP_057556.2,
NP_001258835.1,
NP_001258833.1,
NP_001258834.1
|
| Others |
UniRef100:
UniRef100_Q9P0R6
UniRef90:
UniRef90_Q9P0R6
UniRef50:
UniRef50_Q9P0R6
UniGene:
Hs.4104,
Hs.745067
CCDS:
CCDS32153.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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