[No authors listed]
Chromosome 9 is highly structurally polymorphic. It contains the largest autosomal block of heterochromatin, which is heteromorphic in 6-8% of humans, whereas pericentric inversions occur in more than 1% of the population. The finished euchromatic sequence of chromosome 9 comprises 109,044,351 base pairs and represents >99.6% of the region. Analysis of the sequence reveals many intra- and interchromosomal duplications, including segmental duplications adjacent to both the centromere and the large heterochromatic block. We have annotated 1,149 genes, including genes implicated in male-to-female sex reversal, cancer and neurodegenerative disease, and 426 pseudogenes. The chromosome contains the largest interferon gene cluster in the human genome. There is also a region of exceptionally high gene and G + C content including genes paralogous to those in the major histocompatibility complex. We have also detected recently duplicated genes that exhibit different rates of sequence divergence, presumably reflecting natural selection.
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LINC00476, C9orf92, IZUMO3, FAM205C, FAM157B, FAM27C, FAM27B, GNE, LOC100288842, FAM27E2, SH2D3C, CCDC180, TMEM210, FAM74A7, RCL1, PRR31, TOPORS, RABEPK, CDK9, SIGMAR1, CDKN2A, CDKN2B, UBAC1, ZER1, SEMA4D, ANP32B, SPTLC1, RRAGA, ACTL7B, ACTL7A, SPIN1, SEC61B, SLC27A4, SPACA9, ADAMTS13, CACFD1, INSL6, SLC2A6, RPL35, MAN1B1, DCTN3, KIF12, PALM2, UHRF2, FAM122A, CLTA, COL5A1, COL15A1, NACC2, C9orf116, CARNMT1, C9orf57, C9orf85, C9orf135, LCN8, ANKRD19P, RPP25L, OR13C5, OR13C8, OR13C3, OR13C4, OR13F1, TRPM6, CTSV, RNF38, GLIPR2, DAB2IP, CYLC2, C9orf66, NXNL2, TTLL11, FAM201A, TTC16, SAXO1, FREM1, KIAA2026, C9orf84, KIAA1958, TSTD2, PRUNE2, BRINP1, DBH, STKLD1, KCNV2, TMEM252, QSOX2, ZNF883, DMRT1, ECM2, TOR1A, MEGF9, AAED1, ELAVL2, C9orf72, CCDC171, NAIF1, FAM219A, CCDC107, ANKS6, SUSD3, STOM, ALAD, FANCG, ALDH1B1, FBP1, FKTN, DOLK, HABP4, PTGR1, TRIM32, FOXD4, FNBP1, SETX, ERP44, KDM4C, SMC5, KANK1, FAM120A, VPS13A, BICD2, PHF24, KIAA0368, NCS1, SLC44A1, ANGPTL2, CDK20, DDX58, TMEM245, FRRS1L, CDC26, FUT7, TXNDC8, MAMDC2, C9orf43, SLC24A2, NSMF, ZNF658, SPATA31A7, SPAG8, OR2K2, FBXO10, GBGT1, LHX6, OSTF1, OR1L3, B4GALT1, RANBP6, TRUB2, DNAI1, INVS, SIT1, SPINK4, GLE1, TOR1B, TOR2A, GNG10, GOLGA2, CRB2, SCAI, C9orf47, SPATA31E1, FAM78A, LURAP1L, NTMT1, ANAPC2, PKN3, OBP2B, STOML2, APBA1, IARS, ZDHHC21, ACER2, IFNA1, IFNA4, IFNA5, IFNA13, ADGRD2, OR1J1, OR1B1, KIF24, AQP3, INSL4, AQP7, JAK2, ZNF322P1, SPATA31D3, C9orf153, OR13J1, OR13C2, LCN9, FAM102A, TOMM5, FAM74A1, FAM74A4, ZNF658B, CENPP, C9orf152, PLPP6, C9orf118, ANKRD20A3, ANKRD20A2, NUTM2G, FOXB2, NCBP1, NDUFB6, NINJ1, NPR2, ROR2, OGN, PAEP, DEC1, AK3, PBX3, ABHD17B, EGFL7, CDKN2A-AS1, UBAP1, C9orf114, CHMP5, RAB14, TMEM8B, C9orf78, POLE3, NANS, FBXW5, MRPL50, DIRAS2, HAUS6, BSPRY, APTX, CNTLN, TEX10, UBE2R2, NMRK1, NOL8, SPATA6L, C9orf40, SMU1, PPP2R4, DNAJC25-GNG10, STRBP, HEMGN, DENND4C, RABL6, CDK5RAP2, UBAP2, PLGRKT, CBWD1, RNF20, LRRC8A, OR2S2, IFNK, SH3GLB2, GSN-AS1, BAAT, REXO4, DOLPP1, PTCH1, PTGDS, KCNT1, GBA2, DENND1A, GPR107, INIP, DMRT3, RAD23B, RFX3, RGS3, RLN1, RLN2, RORB, RPL12, DMRTA1, CARD9, SET, BMS1P15, FAM163B, SUSD1, POLR1E, BMS1P11, FAM138A, SH3GL2, SHB, FAM220BP, SPATA31A1, IPPK, DDX31, MRPL41, SLC1A1, NOL6, LRRC37A5P, FOXD4L5, SNAPC3, SNAPC4, SPTAN1, KLF9, TAL2, TLE1, TLE4, TMOD1, TPM2, CNTNAP3B, ANKRD20A4, SKA2P1, LOC730110, C8G, VLDLR, ZNF79, ZNF189, ZFAND5, ZCCHC6, GALNT12, CAAP1, RMI1, TRPM3, NR4A3, PTGES2, BRD3, PDCD1LG2, MIR600HG, URM1, ISCA1, DOCK8, ARPC5L, AIF1L, UCK1, ZNF484, FSD1L, PIP5K1B, ZCCHC7, ANKRD20A1, C9orf64, CARD19, MFSD14C, TMEM246, RECK, MFSD14B, PIGO, PRRC2B, PLPP7, ZDHHC12, C9orf3, TMEM141, ARRDC1-AS1, ALG2, EDF1, CTNNAL1, MPDZ, FBP2, KYAT1, FGD3, WDR34, LRSAM1, IL33, TMEM261, SLC25A51, MRRF, RBM18, ARRDC1, DPH7, ADAMTSL1, CER1, PLAA, FAM189A2, TJP2, MED27, GABBR2, TRIM14, SEC16A, PUM3
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