| Type | Description |
|---|---|
| Definition | aprataxin |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 13:03:00 | Identification of APTX disease-causing mutation in two unrelated Jordanian families with cerebellar ataxia and sensitivity to DNA damaging agents. | 32750061 |
| 2020-03-07 11:08:00 | Aprataxin (APTX) surveils LIG1 activity which suppresses mutagenic and abortive ligation at sites of oxidative DNA damage. APTX provides another tier of damaged DNA substrate discrimination by preferentially intercepting and hydrolyzing AMP-DNA intermediates that contain improper 3' termini. | 31780661 |
| 2019-11-30 11:47:00 | Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in APTX-deficient cells have been reported. | 30986824 |
| 2019-03-30 11:48:00 | These results uncover a DNA-induced fit mechanism regulating APTX active site loop conformations and assembly of a catalytically competent active center. | 29934293 |
| 2018-03-03 11:19:00 | we demonstrated that miR-424 regulated radiosensitivity by directly targeting aprataxin. | 27769049 |
| Type | IDs |
|---|---|
| Synonymous | AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT |
| Gene |
UniProtKB-ID:
APTX_HUMAN
UniprotKB:
Q7Z2E3
UniParc:
UPI00002318C5,
UPI0000074008,
UPI00002318C4,
UPI00001606F5,
UPI00001606F6,
UPI00002318C1,
UPI00001A9DBB,
UPI0000375B76,
UPI00002318C3,
UPI00001606F4,
UPI00001AE449,
UPI00002318C2,
UPI0000375B74
EMBL:
AK055672,
AY302070,
BC001628,
AY208835,
AJ565851,
AY208832,
AY302067,
AY208836,
AY208831,
AY208829,
BC032650,
AY208842,
AY208840,
AJ565854,
AJ565852,
AY302074,
AY208830,
AY208839,
AL353717,
AY302071,
CH471071,
AJ565855,
AY040777,
AY208841,
AY208834,
AJ575566,
AJ565853,
AK000164,
BC104881,
AY208838,
AL162590,
AJ565850,
AY208833,
AY302068,
AY302072,
AY208837,
BX538161
Ensembl:
ENSG00000137074
KO:
hsa:54840
|
| Nucleutide sequences |
EMBL-CDS:
AAH01628.1,
AAP86332.1,
EAW58531.1,
CAD92459.1,
AAP86322.1,
AAQ74137.1,
EAW58529.1,
CAD92455.1,
AAP86325.1,
AAP86331.1,
CAD92457.1,
AAQ74135.1,
CAD92454.1,
AAP86321.1,
AAQ74131.1,
AAI04882.1,
CAD92456.1,
CAD92458.1,
EAW58530.1,
AAQ74133.1,
AAP86326.1,
EAW58534.1,
EAW58532.1,
AAP86329.1,
AAQ74130.1,
CAE01427.1,
BAA90985.1,
AAP86319.1,
AAQ74134.1,
AAP86320.1,
AAP86323.1,
AAP86324.1,
CAD98041.1,
EAW58535.1,
AAH32650.1,
AAP86328.1,
BAG51552.1,
AAP86330.1,
AAK91768.1,
AAP86327.1
Ensembl_TRS:
ENST00000672846,
ENST00000494649,
ENST00000467331,
ENST00000309615,
ENST00000673248,
ENST00000379819,
ENST00000673487,
ENST00000672438,
ENST00000672519,
ENST00000379817,
ENST00000465003,
ENST00000673416,
ENST00000436040,
ENST00000479656,
ENST00000672535,
ENST00000464632,
ENST00000379825,
ENST00000482687,
ENST00000460940,
ENST00000476858,
ENST00000673598,
ENST00000468275,
ENST00000485479,
ENST00000463596
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000400806,
ENSP00000418311,
ENSP00000417634,
ENSP00000500738,
ENSP00000419430,
ENSP00000418144,
ENSP00000369147,
ENSP00000311547,
ENSP00000418069,
ENSP00000419289,
ENSP00000419846,
ENSP00000420071,
ENSP00000369145,
ENSP00000418733,
ENSP00000419042,
ENSP00000420263,
ENSP00000500320,
ENSP00000499997,
ENSP00000500601,
ENSP00000500943,
ENSP00000369153,
ENSP00000500396,
ENSP00000499872,
ENSP00000499991
RefSeq:
NP_001355934.1,
NP_001355924.1,
XP_024303346.1,
NP_001355927.1,
NP_001357599.1,
NP_001357602.1,
NP_001355933.1,
XP_016870321.1,
NP_001355929.1,
NP_001182177.2,
NP_001182179.2,
NP_001355926.1,
XP_016870322.1,
XP_016870320.1,
NP_001355935.1,
NP_001355928.1,
NP_001355930.1,
NP_778239.2,
NP_001355925.1,
NP_001182181.2,
NP_001182178.1,
NP_001355932.1,
NP_001355931.1,
NP_001182180.1,
XP_016870325.1,
NP_778243.1,
XP_011516240.1,
NP_001357598.1,
NP_001182183.1
|
| Others |
UniRef100:
UniRef100_Q7Z2E3
UniRef90:
UniRef90_Q7Z2E3
UniRef50:
UniRef50_Q7Z2E3
UniGene:
Hs.20158
CCDS:
CCDS56568.1,
CCDS6532.1,
CCDS75827.1,
CCDS47956.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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