| Type | Description |
|---|---|
| Definition | serine palmitoyltransferase long chain base subunit 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 11:41:00 | Yhe results revealed that forced expression of SPTLC1 could significantly inhibit cell growth in vitro and in vivo via, at least in part, modulating Akt/FOXO1 signaling pathway, thus representing a novel role of SPTLC1 in the regulation of tumor growth in renal cell carcinoma (RCC). | 31554600 |
| 2019-10-26 11:13:00 | Elevated levels of atypical deoxysphingolipids, caused by variant SPTLC1 or SPTLC2 or by low serine levels, were risk factors for macular telangiectasia type 2, as well as for peripheral neuropathy. | 31509666 |
| 2019-10-19 10:05:00 | This study accomplished a cell-free reconstitution of the sphingolipid regulation of the ORMDL3-SPTLC1 complex to probe the underlying regulatory mechanism. Sphingolipid and ORMDL-dependent regulation of SPTLC1 was demonstrated in isolated membranes, essentially free of cytosol. This suggests that this regulation does not require soluble cytosolic proteins or small molecules such as ATP. | 30700557 |
| 2017-06-10 10:26:00 | Therefore, SPT may be an attractive therapeutic anti-cancer drug target for which compound-2 may be a promising new drug. | 28108287 |
| 2016-12-17 12:11:00 | Hereditary sensory and autonomic neuropathy type 1 mutations in SPTLC1 have distinct biochemical properties, which allowed for the prediction of the clinical symptoms on the basis of the plasma sphingoid base profile. | 26681808 |
| Type | IDs |
|---|---|
| Synonymous | HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI |
| Gene |
UniProtKB-ID:
SPTC1_HUMAN,
Q6NUL7_HUMAN,
A0A024R277_HUMAN
UniprotKB:
O15269,
Q6NUL7,
A0A024R277
UniParc:
UPI000012E27B,
UPI000035367C,
UPI0000073725
EMBL:
BC007085,
AF286705,
AF286703,
Y08685,
AF286711,
AL354751,
AF286717,
AF286712,
AK291546,
AF286707,
AF286710,
AF286713,
AF286709,
AF286708,
AF286715,
CH471089,
AF286716,
AF286706,
AL391219,
AF286704,
BC068537,
AF286714
Ensembl:
ENSG00000090054
KO:
hsa:10558
|
| Nucleutide sequences |
EMBL-CDS:
EAW62804.1,
AAH07085.1,
AAK29328.1,
BAF84235.1,
CAA69941.1,
AAH68537.1,
EAW62805.1
Gene_ORFName:
hCG_1985323
Ensembl_TRS:
ENST00000262554,
ENST00000337841
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000262554,
ENSP00000337635
RefSeq:
XP_016869690.1,
NP_001355201.1,
NP_006406.1,
NP_001355202.1,
XP_024303147.1,
XP_011516440.1,
NP_001268232.1,
NP_847894.1,
XP_024303146.1
|
| Others |
UniRef100:
UniRef100_O15269,
UniRef100_Q6NUL7
UniRef90:
UniRef90_O15269,
UniRef90_Q5R9T5
UniRef50:
UniRef50_O35704,
UniRef50_O15269
UniGene:
Hs.90458
CCDS:
CCDS6692.1,
CCDS6693.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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