SLC24A2 - solute carrier family 24 member 2-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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25769 SLC24A2

基因描述

Type	Description
Definition	solute carrier family 24 member 2

研究结论

Date	Results	Publications
2019-06-15 11:38:00	residues in the two regions with the highest degree of homology between the different NCKX isoforms (alpha-1 and alpha-2 repeats) were examined to determine which residues are important for Ca(2+) coordination.	30173760
2018-03-10 10:41:00	a new mutation in SLC24A2 gene was identified to decrease the stability of SLC24A2	28413183
2013-03-16 11:49:00	Functional and structural properties of the NCKX2 Na(+)-Ca (2+)/K (+) exchanger: a comparison with the NCX1 Na (+)/Ca (2+) exchanger.	23224872
2010-06-28 12:07:00	identified 31 residues that, when substituted, result in shifts in Na(+) affinity, either toward higher or lower K(m) values when compared with wild type NCKX2 (K(m) for Na(+) 58 mm)	20231282
2010-01-21 00:00:00	Glu(188) and Asp(548) are the central residues of a single cation binding pocket that can accommodate both K(+) and Ca(2+). Furthermore, a single set of residues lines a transport pathway for both K(+) and Ca(2+).	15583008

名称对应

Type	IDs
Synonymous	NCKX2
Gene	UniProtKB-ID: NCKX2_HUMAN UniprotKB: Q9UI40 UniParc: UPI000004FA46, UPI000002AF42 EMBL: BC069622, AL158206, BC143889, AF177987, AL133281, AF097366, AL158077 Ensembl: ENSG00000155886 KO: hsa:25769
Nucleutide sequences	EMBL-CDS: AAI43890.1, AAF21810.1, AAF25811.1, AAH69622.1 Ensembl_TRS: ENST00000341998, ENST00000286344
Protein sequencees	Ensembl_PRO: ENSP00000286344, ENSP00000344801 RefSeq: NP_001180217.1, XP_016870081.1, NP_065077.1, NP_001362780.1, NP_001362779.1
Others	UniRef100: UniRef100_Q9UI40 UniRef90: UniRef90_Q9UI40 UniRef50: UniRef50_Q9UI40 UniGene: Hs.283014, Hs.590750, Hs.738749 CCDS: CCDS6493.1, CCDS55297.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
30173760	Residues important for Ca²⁺ ion transport in the neuronal K⁺-dependent Na⁺-Ca²⁺ exchanger (NCKX2). Cell Calcium Ali H Jalloul , Guohong Liu , Robert T Szerencsei , Paul P M Schnetkamp	2018-09-01	-
28413183	A SLC24A2 Gene Variant Uncovered in Pancreatic Ductal Adenocarcinoma by Whole Exome Sequencing. Tohoku J. Exp. Med. Lei Wang , Zhuo Shao , Shiyue Chen , Lu Shi , Zhaoshen Li	2017-04-01	-
26631410	Cation dependencies and turnover rates of the human Kâº-dependent Naâº-CaÂ²âº exchangers NCKX1, NCKX2, NCKX3 and NCKX4. Cell Calcium Ali H Jalloul , Robert T Szerencsei , Paul P M Schnetkamp	2016-01-01	-
23517042	Genome-wide association study of body mass index in 23 000 individuals with and without asthma. Clin. Exp. Allergy E MelÃ©n , R Granell , M Kogevinas , D Strachan , J R Gonzalez , M Wjst , D Jarvis , M Ege , C Braun-FahrlÃ¤nder , J Genuneit , E Horak , E Bouzigon , F Demenais , F Kauffmann , V Siroux , S Michel , A von Berg , A Heinzmann , M Kabesch , N M Probst-Hensch , I Curjuric , M Imboden , T Rochat , J Henderson , J A C Sterne , W L McArdle , J Hui , A L James , A William Musk , L J Palmer , A Becker , A L Kozyrskyj , M Chan-Young , J E Park , A Leung , D Daley , M B Freidin , I A Deev , L M Ogorodova , V P Puzyrev , J C CeledÃ³n , J M Brehm , M M Cloutier , G Canino , E Acosta-PÃ©rez , M Soto-Quiros , L Avila , A BergstrÃ¶m , J Magnusson , C SÃ¶derhÃ¤ll , I Kull , S Scholtens , H Marike Boezen , G H Koppelman , A H Wijga , I Marenholz , J Esparza-Gordillo , S Lau , Y-A Lee , M Standl , C M T Tiesler , C Flexeder , J Heinrich , R A Myers , C Ober , D L Nicolae , M Farrall , A Kumar , M F Moffatt , W O C M Cookson , J Lasky-Su	2013-04-01	-
23224872	Functional and structural properties of the NCKX2 Na(+)-Ca (2+)/K (+) exchanger: a comparison with the NCX1 Na (+)/Ca (2+) exchanger. Adv. Exp. Med. Biol. Haider F Altimimi , Robert T Szerencsei , Paul P M Schnetkamp	2013-01-01	SLC24A2, SLC8A1
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
20231282	Residues contributing to the Na(+)-binding pocket of the SLC24 Na(+)/Ca(2+)-K(+) Exchanger NCKX2. J Biol Chem Haider F Altimimi , Eric H Fung , Robert J Winkfein , Paul P M Schnetkamp	2010-05-14	-
19734545	A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Hum. Mol. Genet. Anna C Need , Deborah K Attix , Jill M McEvoy , Elizabeth T Cirulli , Kristen L Linney , Priscilla Hunt , Dongliang Ge , Erin L Heinzen , Jessica M Maia , Kevin V Shianna , Michael E Weale , Lynn F Cherkas , Gail Clement , Tim D Spector , Greg Gibson , David B Goldstein	2009-12-01	LINC01135, MIR2054, LOC100505530, LOC100506497, LOC101060400, LOC101928387, KCCAT211, CORO2B, ARPP21, PAPD7, BTBD11, CCDC167, FAM91A1, EHHADH, FLT1, PLCB1, GABRB3, SLC24A2, GORASP2, VPS41, GRIN2B, DNAJC15, HCCS, FAM131C, JUN, LMO2, FAM177B, MDM4, VCX3B, MID1, MOBP, UNC13C, MTHFD1, C11orf73, FBXO40, CPVL, VANGL2, TSHZ3, KLHL1, JAM2, RIT2, SEC14L1, SH3GL2, SLC6A6, CAPN5, LOC730100, UCHL1, FAT4, GRIP2, NRIP1, IMMP2L, API5, DSEL, PXYLP1, BICDL1, NRXN1, NCOR2, TOX
19240061	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Gut G Trynka , A Zhernakova , J Romanos , L Franke , K A Hunt , G Turner , M Bruinenberg , G A Heap , M Platteel , A W Ryan , C de Kovel , G K T Holmes , P D Howdle , J R F Walters , D S Sanders , C J J Mulder , M L Mearin , W H M Verbeek , V Trimble , F M Stevens , D Kelleher , D Barisani , M T Bardella , R McManus , D A van Heel , C Wijmenga	2009-08-01	-
18166528	SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis. J Biol Chem Rebecca S Ginger , Sarah E Askew , Richard M Ogborne , Stephen Wilson , Dudley Ferdinando , Tony Dadd , Adrian M Smith , Shubana Kazi , Robert T Szerencsei , Robert J Winkfein , Paul P M Schnetkamp , Martin R Green	2008-02-29	-

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