| Type | Description |
|---|---|
| Definition | multiple PDZ domain crumbs cell polarity complex component |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:52:00 | Observation of nine previously reported and 10 non-reported SLC4A11 mutations among 20 Iranian CHED probands and identification of an MPDZ mutation as possible cause of CHED and FECD in one family. | 31420327 |
| 2020-01-11 11:35:00 | DAPLE and MPDZ function as cooperative partners at apical junctions. | 31268831 |
| 2019-07-27 10:57:00 | Tumor angiogenesis was enhanced upon endothelial-specific inactivation of MPDZ leading to an excessively branched and poorly functional vessel network resulting in tumor hypoxia through DLL4-induced Notch signaling. | 29620522 |
| 2019-06-01 10:06:00 | This study confirmed the association of SNP rs1324183 in MPDZ-NF1B with keratoconus and revealed the association of this SNP with keratoconus severity and corneal parameters. It is thus a putative genetic marker for monitoring the progression of keratoconus to a severe form and facilitating early intervention. | 30002070 |
| 2017-12-09 10:55:00 | two peptides (SIAPNV(-COOH) and SIVMNV(-COOH)) were identified to have considerably improved affinity with K d increase by ~tenfold relative to wild type peptide. Thus, the two peptides are considered as promising lead entities to develop therapeutic molecular agents with high efficacy and specificity to target CaMKIIalpha-MUPP1 interaction. | 26984442 |
| Type | IDs |
|---|---|
| Synonymous | HYC2, MUPP1 |
| Gene |
UniProtKB-ID:
MPDZ_HUMAN
UniprotKB:
O75970
UniParc:
UPI0000211133,
UPI000191706B,
UPI0000151582,
UPI00015367D3
EMBL:
AL353639,
CR936648,
AK098775,
AL162386,
AL161449,
BC144564,
AF093419,
CH471071,
AB210041,
BC140793,
AJ001319
Ensembl:
ENSG00000107186
KO:
hsa:8777
|
| Nucleutide sequences |
EMBL-CDS:
EAW58704.1,
CAI56786.1,
AAI40794.1,
AAI44565.1,
BAC05409.1,
CAA04680.1,
AAC61870.1,
BAE06123.1
Ensembl_TRS:
ENST00000381022,
ENST00000541718,
ENST00000319217,
ENST00000536827,
ENST00000447879
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000370410,
ENSP00000439807,
ENSP00000415208,
ENSP00000444151,
ENSP00000320006
RefSeq:
XP_016870741.1,
XP_016870747.1,
NP_001362352.1,
NP_001362353.1,
XP_006716949.1,
NP_001362354.1,
NP_001362345.1,
NP_001362351.1,
NP_001362348.1,
NP_001362355.1,
XP_024303476.1,
NP_001362356.1,
NP_003820.2,
XP_006716950.1,
XP_016870742.1,
XP_006716951.1,
NP_001362349.1,
NP_001365707.1,
NP_001362342.1,
NP_001362350.1,
NP_001362346.1,
NP_001317566.1,
NP_001248335.1,
NP_001248336.1,
XP_016870748.1,
NP_001362347.1
|
| Others |
UniRef100:
UniRef100_O75970
UniRef90:
UniRef90_O75970
UniRef50:
UniRef50_O75970
UniGene:
Hs.169378
CCDS:
CCDS59119.1,
CCDS59120.1,
CCDS47951.1,
CCDS83342.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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