| Type | Description |
|---|---|
| Definition | F-box and WD repeat domain containing 5 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-18 11:43:00 | Here, the authors show that the F-box protein FBXW5 targets SEC23B, a component of COPII, for proteasomal degradation and that this event limits the autophagic flux in the presence of nutrients. In response to starvation, ULK1 phosphorylates SEC23B on Serine 186, preventing the interaction of SEC23B with FBXW5 and, therefore, inhibiting SEC23B degradation. | 30596474 |
| 2014-06-07 12:21:00 | oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2 | 24444419 |
| 2013-12-14 12:02:00 | DLC1 was ubiquitinated and degraded by cullin 4A-RING ubiquitin ligase (CRL4A) complex interaction with DDB1 and the FBXW5 substrate receptor. | 24082123 |
| 2013-03-30 12:17:00 | Identify Fbxw5-driven fluctuation of Eps8 levels as an important mechanism that contributes to cell-shape changes during entry into-and exit from-mitosis. | 23314863 |
| 2013-02-02 11:27:00 | Fbxw5 enhances sumoylation of nuclear c-Myb | 22910413 |
| Type | IDs |
|---|---|
| Synonymous | Fbw5 |
| Gene |
UniProtKB-ID:
FBXW5_HUMAN,
A0A024R8H7_HUMAN
UniprotKB:
Q969U6,
A0A024R8H7
UniParc:
UPI000006EC75,
UPI000023FF06
EMBL:
BC014130,
BC000850,
AB209726,
AL137631,
BC004541,
AL807752,
BC009429,
AF258569,
AK315738,
CH471090,
BC014297,
AF217998,
AK026081
Ensembl:
ENSG00000159069
KO:
hsa:54461
|
| Nucleutide sequences |
EMBL-CDS:
AAH09429.1,
AAG23772.1,
BAD92963.1,
AAH14130.1,
BAG38093.1,
AAH04541.2,
EAW88307.1,
CAB70851.1,
BAB15354.1,
AAG17240.1,
AAH00850.1,
AAH14297.1,
EAW88311.1,
EAW88315.1,
EAW88313.1
Gene_ORFName:
PP3971,
hCG_93856
Ensembl_TRS:
ENST00000325285
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000313034
RefSeq:
XP_011517091.1,
NP_061871.1,
XP_005266146.2,
XP_016870301.1
|
| Others |
UniRef100:
UniRef100_Q969U6
UniRef90:
UniRef90_Q969U6
UniRef50:
UniRef50_Q969U6
UniGene:
Hs.522507
CCDS:
CCDS7014.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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