TRPM3 - transient receptor potential cation channel subfamily M member 3-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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80036 TRPM3

基因描述

Type	Description
Definition	transient receptor potential cation channel subfamily M member 3

研究结论

Date	Results	Publications
2021-03-20 13:27:00	Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy.	32427099
2021-03-06 13:30:00	TRPM3 channel activation inhibits contraction of the isolated human ureter via CGRP released from sensory nerves.	33417951
2021-02-13 13:25:00	Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes.	32575443
2021-02-02 13:28:00	The structural basis for an on-off switch controlling Gbetagamma-mediated inhibition of TRPM3 channels.	33122432
2020-10-24 14:00:00	Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.	31736966

名称对应

Type	IDs
Synonymous	GON-2, LTRPC3, MLSN2
Gene	UniProtKB-ID: TRPM3_HUMAN, Q9H200_HUMAN, G5E9G1_HUMAN, E9PBI7_HUMAN, Q6NW43_HUMAN, H7BYP1_HUMAN, A2A3F4_HUMAN, A2A3F7_HUMAN UniprotKB: Q9HCF6, Q9H200, G5E9G1, E9PBI7, Q6NW43, H7BYP1, A2A3F4, A2A3F7 UniParc: UPI0000EE5553, UPI0000190903, UPI0000457761, UPI0001F4E02A, UPI0001596895, UPI00003519A9, UPI0000457760, UPI000045775F, UPI00003507F3, UPI0000D6188E, UPI0001F4E02D, UPI0001F4E02B, UPI0001F4E02F, UPI0001F4E02C, UPI0001F4E02E, UPI0001F4E030, UPI000006D74C, UPI000066DA55 EMBL: AL136545, BC121821, AF325212, AF536748, AB046836, AL358786, AF536749, BC142972, AB099665, AJ505026, AL442645, CH471089, AF536752, AB099661, AB099663, AL356318, AL391819, AF536750, AL159990, AF536753, AJ505025, AL160273, BC067733, AL161913, KF458923, AB099664, AL592438, BC134414, AB099662, AF536751 Ensembl: ENSG00000083067 KO: hsa:80036
Nucleutide sequences	EMBL-CDS: BAC55102.1, BAC55103.1, CAD43604.1, BAC55106.1, AAO49156.1, BAC55105.1, AAO49158.1, AAI34415.1, CAD43605.1, AAI42973.1, CAB66480.2, AAO49154.1, BAC55104.1, BAB13442.1, AAO49153.1, AAI21822.2, AAO49157.1, AAO49155.1, AAG42856.1, EAW62505.1, AAH67733.1, EAW62507.1 Gene_ORFName: hCG_2042991, hCG_2042991 Ensembl_TRS: ENST00000377111, ENST00000377110, ENST00000361823, ENST00000408909, ENST00000377105, ENST00000396292, ENST00000396280, ENST00000358082, ENST00000360823, ENST00000357533
Protein sequencees	Ensembl_PRO: ENSP00000366314, ENSP00000355395, ENSP00000366315, ENSP00000386127, ENSP00000366309, ENSP00000379587, ENSP00000379576, ENSP00000354066, ENSP00000350791, ENSP00000350140 RefSeq: XP_011517348.1, NP_996829.3, NP_001353070.1, XP_011517347.1, XP_024303450.1, XP_011517340.1, NP_001007471.1, NP_996828.3, NP_996830.3, XP_024303454.1, XP_024303453.1, NP_001353074.1, XP_024303455.1, NP_001353073.1, NP_996831.1, XP_024303449.1, NP_001353075.1, NP_001353071.1, NP_001353072.1, NP_001353080.1, NP_001353077.1, NP_001007472.2, XP_011517339.1, XP_024303451.1, XP_011517342.1, XP_011517344.1, NP_996827.3, NP_001353083.1, NP_079247.5, XP_011517341.1, NP_001353082.1, NP_001353076.1, NP_066003.3, NP_001353081.1, XP_016870645.1, XP_024303452.1, NP_001353079.1, NP_001353078.1
Others	UniRef100: UniRef100_G5E9G1, UniRef100_Q9H200, UniRef100_Q6NW43, UniRef100_E9PBI7, UniRef100_A2A3F4, UniRef100_A2A3F7, UniRef100_Q9HCF6 UniRef90: UniRef90_A2A3F4, UniRef90_E9PBI7, UniRef90_A2A3F7, UniRef90_H3AQC4, UniRef90_Q8BKI1, UniRef90_G5E9G1, UniRef90_Q9HCF6 UniRef50: UniRef50_Q8BKI1, UniRef50_Q9HCF6, UniRef50_A0A096M005 UniGene: Hs.47288 CCDS: CCDS43835.1, CCDS6637.1

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mRNA

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Pubmed编号	文献信息	发表日期	相关基因
33417951	TRPM3 channel activation inhibits contraction of the isolated human ureter via CGRP released from sensory nerves. Life Sci Jiaxin Liu , Mengmeng Zhao , Zhenghao Chen , Yang Xu , Liqiang Guo , Shaoyong Wang , Yan Li , Benkang Shi , Xiulin Zhang , Xiao-Dong Jin	2021-03-01	-
33122432	The structural basis for an on-off switch controlling GÎ²Î³-mediated inhibition of TRPM3 channels. Proc Natl Acad Sci U S A Marc Behrendt , Fabian Gruss , Raissa Enzeroth , Sandeep Dembla , Siyuan Zhao , Pierre-Antoine Crassous , Florian Mohr , Mieke Nys , Nikolaos Louros , Rodrigo Gallardo , Valentina Zorzini , Doris Wagner , Anastassios Economou , Frederic Rousseau , Joost Schymkowitz , Stephan E Philipp , Tibor Rohacs , Chris Ulens , Johannes Oberwinkler	2020-11-17	-
32575443	Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes. Int J Mol Sci JÃ¶rn LÃ¶tsch , Dario Kringel , Gerd Geisslinger , Bruno G Oertel , Eduard Resch , Sebastian Malkusch	2020-06-19	-
32427099	Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy. Elife Evelien Van Hoeymissen , Katharina Held , Ana Cristina Nogueira Freitas , Annelies Janssens , Thomas Voets , Joris Vriens	2020-05-19	-
31796045	Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients. J Transl Med Cassandra Balinas , Helene Cabanas , Donald Staines , Sonya Marshall-Gradisnik	2019-12-03	-
31451581	Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by GÎ²Î³ Subunits. J Neurosci Omar Alkhatib , Robson da Costa , Clive Gentry , Talisia Quallo , Stuart Bevan , David A Andersson	2019-10-02	-
31278393	De novo substitutions of TRPM3 cause intellectual disability and epilepsy. Eur J Hum Genet David A Dyment , Paulien A Terhal , Cecilie F Rustad , Kristian Tveten , Christopher Griffith , Parul Jayakar , Marwan Shinawi , Sara Ellingwood , Rosemarie Smith , Koen van Gassen , Kirsty McWalter , A Micheil Innes , Matthew A Lines	2019-10-01	-
31014226	Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients. Mol. Med. H Cabanas , K Muraki , C Balinas , N Eaton-Fitch , D Staines , S Marshall-Gradisnik	2019-04-23	-
30552902	Stimulation of TRPM3 channels increases the transcriptional activation potential of Elk-1 involving cytosolic Ca²⁺, extracellular signal-regulated protein kinase, and calcineurin. Eur. J. Pharmacol. Sandra Rubil , Gerald Thiel	2019-02-05	-
31736966	Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. Front Immunol Helene Cabanas , Katsuhiko Muraki , Donald Staines , Sonya Marshall-Gradisnik	2019-01-01	-

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