| Type | Description |
|---|---|
| Definition | ubiquitin conjugating enzyme E2 R2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 10:32:00 | UBE2R2 alone had negligible ubiquitylation activity at physiological concentrations and the ablation of UBE2R1/2 had no effect on the stability of SCF substrates in cells. A genome-wide CRISPR screen revealed that an additional E2 enzyme, UBE2G1, buffers against the loss of UBE2R1/2. | 31868589 |
| 2017-05-27 11:50:00 | Study shows that Ube2R1/2 forms a salt bridge interaction between a conserved Asp residue on Ube2R1/2 and acceptor ubiquitin residue Arg 54 and that perturbation of this interaction leads to the severe loss of UbeR2 activity. Results also provide new insight into how the Ube2R1/2 acidic loop may participate in catalysis. | 27044868 |
| 2010-06-30 22:05:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| 2010-04-07 21:40:00 | Observational study of gene-disease association. (HuGE Navigator) | 20198315 |
| 2010-01-21 00:00:00 | Protein kinase CK2 dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TRCp and enhances beta-catenin degradation [UBC3B] | 12037680 |
| Type | IDs |
|---|---|
| Synonymous | CDC34B, E2-CDC34B, UBC3B |
| Gene |
UniProtKB-ID:
UB2R2_HUMAN
UniprotKB:
Q712K3
UniParc:
UPI0000000C64
EMBL:
BC047584,
BC004862,
AJ240087,
AL139113,
CH471071,
CR457233,
AK000426
Ensembl:
ENSG00000107341
KO:
hsa:54926
|
| Nucleutide sequences |
EMBL-CDS:
AAH04862.1,
CAC80336.1,
EAW58479.1,
CAG33514.1,
AAH47584.1,
BAA91156.1,
EAW58480.1
Ensembl_TRS:
ENST00000263228
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000263228
RefSeq:
XP_005251553.1,
XP_016870349.1,
XP_011516251.1,
NP_060281.2
|
| Others |
UniRef100:
UniRef100_Q712K3
UniRef90:
UniRef90_Q712K3
UniRef50:
UniRef50_Q712K3
UniGene:
Hs.643648
CCDS:
CCDS6546.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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