| Type | Description |
|---|---|
| Definition | TOP1 binding arginine/serine rich protein |
| Date | Results | Publications |
|---|---|---|
| 2017-12-02 12:25:00 | A novel mutation of the TOPORS gene was identified, c.2539C>T p.(Arg847Ter), resulting in a premature termination codon and suggesting haploinsufficiency as the pathological mechanism. | 28453362 |
| 2016-07-30 11:41:00 | P26s4 Associates with the C-Terminal Region of TOPORS. | 26872363 |
| 2013-05-04 13:22:00 | Data suggest that TOPORS plays key role in turnover of H2AX (H2A histone family, member X protein) depending on the type of oxidative stress/DNA damage; TOPORS may act as an E3 ubiquitin ligase for histones. | 22972498 |
| 2011-09-03 11:39:00 | Disturbed flow induces peroxynitrite production and binding to the E3 SUMO (small ubiquitin-like modifier) ligase PIASy (protein inhibitor of activated | 21624951 |
| 2011-05-28 11:28:00 | In photoreceptors, TOPORS localizes primarily to the basal bodies of connecting cilium and in the centrosomes. | 21159800 |
| Type | IDs |
|---|---|
| Synonymous | LUN, P53BP3, RP31, TP53BPL |
| Gene |
UniProtKB-ID:
TOPRS_HUMAN
UniprotKB:
Q9NS56
UniParc:
UPI000006F223,
UPI0000072A6B
EMBL:
AF098300,
AB045733,
BC060884,
AL353671,
AB045732,
U82939
Ensembl:
ENSG00000197579
KO:
hsa:10210
|
| Nucleutide sequences |
EMBL-CDS:
AAH60884.1,
BAB03715.1,
AAD23379.1,
AAC98530.1,
BAB03714.1
Ensembl_TRS:
ENST00000379858,
ENST00000360538
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000353735,
ENSP00000369187
RefSeq:
NP_001182551.1,
NP_005793.2
|
| Others |
UniRef100:
UniRef100_Q9NS56
UniRef90:
UniRef90_Q9NS56
UniRef50:
UniRef50_Q9NS56
UniGene:
Hs.589962
CCDS:
CCDS6527.1,
CCDS56566.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员