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10670 RRAGA

10670

RRAGA

Ras related GTP binding A

protein-coding

Homo sapiens

基因描述

Type Description
Definition Ras related GTP binding A

研究结论

Date Results Publications
2021-03-13 13:17:00 The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both and Growth Factor Restriction. 32898476
2021-02-06 13:55:00 Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation. 33340489
2021-02-02 13:27:00 Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9. 32868926
2020-05-02 10:58:00 cryo-electron microscopy structure of RagA/RagC in complex with mTORC1 shows the details of RagA/RagC binding to the RAPTOR subunit of mTORC1 and explains why only the RagAGTP/RagCGDP nucleotide state binds mTORC1 31601764
2020-04-25 11:51:00 The Raptor alpha-solenoid directly detects the nucleotide state of RagA while the Raptor "claw" threads between the GTPase domains to detect that of RagC. Mutations that disrupted Rag-Raptor binding inhibited mTORC1 lysosomal localization and signaling. 31601708

名称对应

Type IDs
Synonymous FIP-1, FIP1, RAGA
Gene
UniProtKB-ID: RRAGA_HUMAN
UniprotKB: Q7L523
UniParc: UPI000006D235
EMBL: U41654, CH471071, BC009990, X90529, AL356000, AK313023, BC006433
Ensembl: ENSG00000155876
KO: hsa:10670
Nucleutide sequences
EMBL-CDS: BAG35858.1, CAA62131.1, EAW58653.1, AAH06433.1, AAH09990.1, AAB63255.1
Ensembl_TRS: ENST00000380527
Protein sequencees
Ensembl_PRO: ENSP00000369899
RefSeq: NP_006561.1
Others
UniRef100: UniRef100_Q7L523
UniRef90: UniRef90_Q7L523
UniRef50: UniRef50_Q7L523
UniGene: Hs.743260
CCDS: CCDS6488.1

全选

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研究热度

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