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7436 VLDLR

7436

VLDLR

very low density lipoprotein receptor

protein-coding

Homo sapiens

基因描述

Type Description
Definition very low density lipoprotein receptor

研究结论

Date Results Publications
2020-02-29 11:35:00 Four single nucleotide polymorphisms (SNPs); rs6921438 and rs4416670 in LOC100132354-C6orf223, rs6993770 in ZFPM2, and rs10738760 in VLDLR-KCNV2 were reported to explain up to 50% of the heritability of vascular endothelial growth factor circulating levels. These SNPs were also studied for possible associations with circulating lipid levels in supposedly healthy European individuals and in a limited number of Iranian indi 31405227
2019-12-14 12:01:00 Postprandial VLDL particles are strongly bound and internalized into cells expressing the VLDL receptor. The presence of various specific ligands in VLDL remnants may enhance the capacity for binding to the VLDL receptor, which play the role primarily for energy delivery to the peripheral tissues, but is also a causal factor in atherogenic diseases when excessively and/or continuously remained in plasma. 31078566
2019-06-29 11:33:00 This study presents the nuclear magnetic resonance solution structure of the recombinant VLDLR(2-4) fragment containing all three fibrin-binding cysteine-rich (CR) domains of this receptor. 29965730
2018-12-01 10:12:00 In summary, ER retention of pathogenic VLDLR mutants involves binding to calnexin, elevated endoplasmic reticulum stress, and delayed degradation which is dependent on SEL1L. 29371607
2018-07-14 10:13:00 Our findings described an atherogenic phenotype characterized by low VLDL-C but high VLDLR mRNA expression in peripheral WBCs, which suggested that VLDLR in all types of peripheral WBCs may be involved in lipid deposition, and VLDL-C and VLDLR may co-determine the development of atherosclerosis. 29042132

名称对应

Type IDs
Synonymous CAMRQ1, CARMQ1, CHRMQ1, VLDL-R, VLDLRCH
Gene
UniProtKB-ID: VLDLR_HUMAN, Q5VVF5_HUMAN
UniprotKB: P98155, Q5VVF5
UniParc: UPI0000055935, UPI000002AD1B
EMBL: DQ067198, D16493, L20470, BC144245, AL450467, D16532, D16494, BC136562, L22431, S73849, BC142653, CH471071
Ensembl: ENSG00000147852
KO: hsa:7436
Nucleutide sequences
EMBL-CDS: AAY46157.1, AAA61344.1, EAW58806.1, AAI36563.1, AAA53684.1, BAA03969.1, AAB31735.1, BAA03946.1, EAW58805.1, BAA03945.1, EAW58807.1, AAI44246.1, EAW58804.1, AAI42654.1
Gene_ORFName: hCG_27927
Ensembl_TRS: ENST00000382099, ENST00000382100
Protein sequencees
Ensembl_PRO: ENSP00000371532, ENSP00000371531
RefSeq: NP_001309155.1, NP_001309154.1, NP_001018066.1, NP_003374.3
Others
UniRef100: UniRef100_P98155, UniRef100_Q5VVF5
UniRef90: UniRef90_P98155
UniRef50: UniRef50_P98155
UniGene: Hs.370422
CCDS: CCDS34979.1, CCDS6446.1

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