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2733 GLE1

2733

GLE1

GLE1 RNA export mediator

protein-coding

Homo sapiens

基因描述

Type Description
Definition GLE1 RNA export mediator

研究结论

Date Results Publications
2020-03-07 12:43:00 This study supports models wherein SGs play a role in cell evasion of apoptosis and further reveal Gle1A and SG functions as targets for clinical approaches directed at chemoresistant/refractory cells. 30262214
2019-06-22 10:28:00 Results found that Nup159 did not accelerate ADP release, while Gle1 actually slowed it independently of Mg(2+) which is not consistent with Nup159 acting as a nucleotide exchange factor to promote ADP release and Dbp5 ATPase cycling. Instead, in the presence of Nup159, the interaction between Gle1 and ADP-bound Dbp5 was found more reduced, suggesting that Nup159 alters the Dbp5-Gle1 to aid Gle1 release from Dbp5. 29782832
2019-05-04 10:28:00 Mitogen-activated protein kinases and glycogen synthase kinase 3 phosphorylate Gle1A and thereby coordinate stress granule dynamics by altering DDX3 function. 30429220
2019-03-23 11:42:00 preliminary data show an intriguing expression profile of Gle1, MART3 and FUS genes in Spinal muscular atrophy (SMA), and suggest a critical role of FUS protein in the SMA pathogenesis. 30565205
2018-10-06 12:00:00 Pathogenic variants in the GLE1 gene are rare in Chinese ALS patients. 29398120

名称对应

Type IDs
Synonymous CAAHC, CAAHD, GLE1L, LCCS, LCCS1, hGLE1
Gene
UniProtKB-ID: GLE1_HUMAN, B3KMG0_HUMAN
UniprotKB: Q53GS7, B3KMG0
UniParc: UPI000013EF77, UPI000006DA45, UPI000015F3AA
EMBL: AK222854, AL356481, AL445287, AK001767, AF058922, AL117584, AK222842, BC030012
Ensembl: ENSG00000119392
KO: hsa:2733
Nucleutide sequences
EMBL-CDS: BAD96562.1, AAH30012.1, BAD96574.1, CAB56006.1, AAC25561.1, BAG50972.1
Ensembl_TRS: ENST00000309971, ENST00000372770
Protein sequencees
Ensembl_PRO: ENSP00000308622, ENSP00000361856
RefSeq: NP_001490.1, XP_024303287.1, NP_001003722.1, XP_011516851.1, XP_011516853.1, XP_011516852.1, XP_006717123.1, XP_006717122.1
Others
UniRef100: UniRef100_B3KMG0, UniRef100_Q53GS7
UniRef90: UniRef90_Q53GS7
UniRef50: UniRef50_Q53GS7
UniGene: Hs.522418
CCDS: CCDS35154.1, CCDS6904.1

全选

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