INSL4 - insulin like 4-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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3641 INSL4

基因描述

Type	Description
Definition	insulin like 4

研究结论

Date	Results	Publications
2020-07-11 11:41:00	LKB1 deficiency induces an autocrine INSL4 signaling that critically supports the growth and survival of lung cancer cells. Therefore, aberrant INSL4 signaling is a promising therapeutic target for LKB1-deficient lung cancers.	30423141
2014-01-11 10:11:00	Report decreased INSL4 gene expression in both the invasive and the noninvasive areas of villous trophoblast in patients with placenta accreta.	23302396
2010-01-21 00:00:00	Expression of the INSL4 gene was doubled in the placenta of the growth-restricted twin compared to the normally grown sibling, suggesting that it may be linked to a higher level of apoptosis and loss of cell viability	15958731
2010-01-21 00:00:00	We identified an INSL4 alternatively spliced mRNA species that encodes putative novel INSL4-like peptides.	12606452
2010-01-21 00:00:00	A tight interaction between HER-2 gene and EPIL in invasive breast cancer cells is probable.	18035692

名称对应

Type	IDs
Synonymous	EPIL, PLACENTIN
Gene	UniProtKB-ID: INSL4_HUMAN UniprotKB: Q14641 UniParc: UPI0000032F5A EMBL: L34838, AK291543, AL133547, CH471071, BC026254 Ensembl: ENSG00000120211 KO: hsa:3641
Nucleutide sequences	EMBL-CDS: AAB08516.1, BAF84232.1, AAH26254.1, EAW58772.1 Ensembl_TRS: ENST00000239316
Protein sequencees	Ensembl_PRO: ENSP00000239316 RefSeq: NP_002186.1
Others	UniRef100: UniRef100_Q14641 UniRef90: UniRef90_Q14641 UniRef50: UniRef50_Q14641 UniGene: Hs.418506 CCDS: CCDS6459.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Ensembl: {{protein.nucleotideEnsembl}}

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Ensembl: {{protein.proteinEnsembl}}

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Definition: {{{protein.definition}}}

Transcript Veriant:{{protein.transcriptVeriant}}

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Location

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Pubmed编号	文献信息	发表日期	相关基因
30423141	Role of INSL4 Signaling in Sustaining the Growth and Viability of LKB1-Inactivated Lung Cancer. J Natl Cancer Inst Rongqiang Yang , Steven W Li , Zirong Chen , Xin Zhou , Wei Ni , Dongtao A Fu , Jianrong Lu , Frederic J Kaye , Lizi Wu	2019-07-01	-
23302396	Relaxin, its receptor (RXFP1), and insulin-like peptide 4 expression through gestation and in placenta accreta. Reprod Sci William Goh , Sandra Y Yamamoto , Karen S Thompson , Gillian D Bryant-Greenwood	2013-08-01	INSL4, RXFP1
19915573	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nat Genet Kouichi Asano , Tomonaga Matsushita , Junji Umeno , Naoya Hosono , Atsushi Takahashi , Takahisa Kawaguchi , Takayuki Matsumoto , Toshiyuki Matsui , Yoichi Kakuta , Yoshitaka Kinouchi , Tooru Shimosegawa , Masayo Hosokawa , Yoshiaki Arimura , Yasuhisa Shinomura , Yutaka Kiyohara , Tatsuhiko Tsunoda , Naoyuki Kamatani , Mitsuo Iida , Yusuke Nakamura , Michiaki Kubo	2009-12-01	-
15958731	Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth. Biol. Reprod. Lynnae Millar , Nicole Streiner , Lisa Webster , Sandra Yamamoto , Rachel Okabe , Tasha Kawamata , Jacqueline Shimoda , Erika BÃ¼llesbach , Christian Schwabe , Gillian Bryant-Greenwood	2005-10-01	INSL4
18035692	[Expression of early placenta insulin-like growth factor (EPIL) in breast cancer cells provides an autocrine loop with enhancement of predominantly HER-2-related invasivity]. Verh Dtsch Ges Pathol H BÃ¼rger , D Kemming , M Helms , U Feldmann , A Matuschek , W BÃ¶cker , B Brandt	2005-01-01	ERBB2, INSL4
15340161	Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. Zemin Zhang , William J Henzel	2004-10-01	C17orf99, INSL5, IL18BP, CALCRL, ANGPTL7, FSTL3, BTN3A3, FST, SEMA6B, SEMA4B, AGR2, SPINT2, CEACAM7, UTS2, EDAR, IL24, LILRA3, FSTL1, NXPH3, IL17F, VSIG4, SCRG1, PIK3IP1, PGLYRP2, SLAMF6, C1QTNF5, C1QTNF6, TMEM123, CTHRC1, IL22RA2, DCD, MUCL1, JAML, CST9L, REG3G, LYPD6, CD200R1, IL31RA, CBLN4, DEFB127, CD300LF, CD300LG, CST1, CST2, CST3, CTSW, AGR3, PEBP4, CLEC14A, DEFA1, DPEP1, EFNA1, EFNA4, EFNB1, EFNB3, EGFR, MPZL3, LCTL, ADAM32, EPHB1, EPHB6, LRRC55, FCGR1A, FCGRT, FCN1, ADGRG3, FGFR4, NTNG1, DKK1, FLT4, VSIG2, PLA2G15, TMEFF2, IL17RA, FLRT2, FRZB, EPGN, GLIPR1L1, SLC39A6, BAMBI, PARM1, CHRDL2, IL4I1, FGF21, PCOLCE2, GREM1, GFRA3, NPTN, DKK4, DKK3, ANGPTL3, OLFML1, CD163L1, VMO1, CXCL17, LYPD5, VSTM1, PRRT3, CXCL1
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team	2004-10-01	Ldlrap1, Dnajc3, Rnaset2a, Btnl1, Isg15, Cyp3a41b, Ly6c2, Ccl21b, Eif3j2, Mup18, Lrrc19, Rcc1, 1700047I17Rik2, Pcsk9, Adat3, Tdrd7, Sco2, Gpr153, Pafah2, Gm44504, H6pd, Adprhl2, Gpn2, Rusc2, Stx12, Ppp1r8, Smpdl3b, Fam46b, Bsdc1, Slc44a1, Zfand2a, Rubcn, Kifc1, Pifo, C030017K20Rik, Cbarp, Rpl5, Micalcl, Atg14, Lrrc8c, Noc4l, Nsun5, Psph, Trrap, Mapre3, Ube3c, Tbc1d14, Hscb, Tyw1, Emilin1, Rab28, Pot1a, Parp11, Tada3, Tra2a, Brk1, Fbxl14, Phrf1, Plekha1, Gm21975, Ric8a, Mob2, Prkd2, Ccp110, Vrk3, Grwd1, Nlrp6, Trim68, Psip1, Spred3, Faap24, Ints4, Rrp8, Unc45a, Igflr1, Sf3b3, D8Ertd738e, Usb1, Champ1, Smim19, Exoc8, Gadd45gip1, Phkb, Dohh, Fam192a, Enkd1, Taf5l, Zdhhc7, Snapc2, Ak6, Gpat4, Dcun1d2, Ankrd10, Cog4, Hinfp, Lars2, Xylb, Imp3, Cmtm7
15164053	DNA sequence and analysis of human chromosome 9. Nature S J Humphray , K Oliver , A R Hunt , R W Plumb , J E Loveland , K L Howe , T D Andrews , S Searle , S E Hunt , C E Scott , M C Jones , R Ainscough , J P Almeida , K D Ambrose , R I S Ashwell , A K Babbage , S Babbage , C L Bagguley , J Bailey , R Banerjee , D J Barker , K F Barlow , K Bates , H Beasley , O Beasley , C P Bird , S Bray-Allen , A J Brown , J Y Brown , D Burford , W Burrill , J Burton , C Carder , N P Carter , J C Chapman , Y Chen , G Clarke , S Y Clark , C M Clee , S Clegg , R E Collier , N Corby , M Crosier , A T Cummings , J Davies , P Dhami , M Dunn , I Dutta , L W Dyer , M E Earthrowl , L Faulkner , C J Fleming , A Frankish , J A Frankland , L French , D G Fricker , P Garner , J Garnett , J Ghori , J G R Gilbert , C Glison , D V Grafham , S Gribble , C Griffiths , S Griffiths-Jones , R Grocock , J Guy , R E Hall , S Hammond , J L Harley , E S I Harrison , E A Hart , P D Heath , C D Henderson , B L Hopkins , P J Howard , P J Howden , E Huckle , C Johnson , D Johnson , A A Joy , M Kay , S Keenan , J K Kershaw , A M Kimberley , A King , A Knights , G K Laird , C Langford , S Lawlor , D A Leongamornlert , M Leversha , C Lloyd , D M Lloyd , J Lovell , S Martin , M Mashreghi-Mohammadi , L Matthews , S McLaren , K E McLay , A McMurray , S Milne , T Nickerson , J Nisbett , G Nordsiek , A V Pearce , A I Peck , K M Porter , R Pandian , S Pelan , B Phillimore , S Povey , Y Ramsey , V Rand , M Scharfe , H K Sehra , R Shownkeen , S K Sims , C D Skuce , M Smith , C A Steward , D Swarbreck , N Sycamore , J Tester , A Thorpe , A Tracey , A Tromans , D W Thomas , M Wall , J M Wallis , A P West , S L Whitehead , D L Willey , S A Williams , L Wilming , P W Wray , L Young , J L Ashurst , A Coulson , H BlÃ¶cker , R Durbin , J E Sulston , T Hubbard , M J Jackson , D R Bentley , S Beck , J Rogers , I Dunham	2004-05-27	LINC00476, C9orf92, IZUMO3, FAM205C, FAM157B, FAM27C, FAM27B, GNE, LOC100288842, FAM27E2, SH2D3C, CCDC180, TMEM210, FAM74A7, RCL1, PRR31, TOPORS, RABEPK, CDK9, SIGMAR1, CDKN2A, CDKN2B, UBAC1, ZER1, SEMA4D, ANP32B, SPTLC1, RRAGA, ACTL7B, ACTL7A, SPIN1, SEC61B, SLC27A4, SPACA9, ADAMTS13, CACFD1, INSL6, SLC2A6, RPL35, MAN1B1, DCTN3, KIF12, PALM2, UHRF2, FAM122A, CLTA, COL5A1, COL15A1, NACC2, C9orf116, CARNMT1, C9orf57, C9orf85, C9orf135, LCN8, ANKRD19P, RPP25L, OR13C5, OR13C8, OR13C3, OR13C4, OR13F1, TRPM6, CTSV, RNF38, GLIPR2, DAB2IP, CYLC2, C9orf66, NXNL2, TTLL11, FAM201A, TTC16, SAXO1, FREM1, KIAA2026, C9orf84, KIAA1958, TSTD2, PRUNE2, BRINP1, DBH, STKLD1, KCNV2, TMEM252, QSOX2, ZNF883, DMRT1, ECM2, TOR1A, MEGF9, AAED1, ELAVL2, C9orf72, CCDC171, NAIF1, FAM219A, CCDC107, ANKS6
12606452	Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element. Biol. Reprod. Ivan BiÃ¨che , Anne Laurent , Ingrid Laurendeau , Laurent Duret , Yves Giovangrandi , Jean-Louis Frendo , Martine Olivi , Jean-Luc Fausser , DaniÃ¨le Evain-Brion , Michel Vidaud	2003-04-01	INSL4
12477932	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. Robert L Strausberg , Elise A Feingold , Lynette H Grouse , Jeffery G Derge , Richard D Klausner , Francis S Collins , Lukas Wagner , Carolyn M Shenmen , Gregory D Schuler , Stephen F Altschul , Barry Zeeberg , Kenneth H Buetow , Carl F Schaefer , Narayan K Bhat , Ralph F Hopkins , Heather Jordan , Troy Moore , Steve I Max , Jun Wang , Florence Hsieh , Luda Diatchenko , Kate Marusina , Andrew A Farmer , Gerald M Rubin , Ling Hong , Mark Stapleton , M Bento Soares , Maria F Bonaldo , Tom L Casavant , Todd E Scheetz , Michael J Brownstein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Christa Prange , Sam S Raha , Naomi A Loquellano , Garrick J Peters , Rick D Abramson , Sara J Mullahy , Stephanie A Bosak , Paul J McEwan , Kevin J McKernan , Joel A Malek , Preethi H Gunaratne , Stephen Richards , Kim C Worley , Sarah Hale , Angela M Garcia , Laura J Gay , Stephen W Hulyk , Debbie K Villalon , Donna M Muzny , Erica J Sodergren , Xiuhua Lu , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madan , Alice C Young , Yuriy Shevchenko , Gerard G Bouffard , Robert W Blakesley , Jeffrey W Touchman , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Martin I Krzywinski , Ursula Skalska , Duane E Smailus , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Marco A Marra , Mammalian Gene Collection Program Team	2002-12-24	-

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