| Type | Description |
|---|---|
| Definition | alkaline ceramidase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:09:00 | TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer. | 33093451 |
| 2019-09-21 12:14:00 | These results suggest that p53 mediates DDR and exerts its tumor suppressive role in part by regulating the expression of ACER2, which in turn regulates the bioactive sphingolipid lipids. | 29229990 |
| 2018-11-10 10:42:00 | Consistently, forced expression of p53 significantly stimulated ACER2 transcription. Notably, p53-mediated autophagy and apoptosis were markedly enhanced by ACER2. Depletion of the essential autophagy gene ATG5 revealed that ACER2-induced autophagy facilitates its effect on apoptosis. | 28294157 |
| 2017-02-18 10:20:00 | Results suggest that the ACER2/sphingosine pathway mediates programmed cell death in response to DNA damage through production. | 26943039 |
| 2014-07-19 11:40:00 | c-Src-mediated signal positively regulates ACER activity in a Ca2+-independent manner. | 24708996 |
| Type | IDs |
|---|---|
| Synonymous | ALKCDase2, ASAH3L |
| Gene |
UniProtKB-ID:
ACER2_HUMAN,
B3KVV5_HUMAN
UniprotKB:
Q5QJU3,
B3KVV5
UniParc:
UPI000022D8C9,
UPI00004A23DA,
UPI000014042D,
UPI000022EE43
EMBL:
AL158206,
AY312516,
BC092487,
AL391834,
AF370405,
AK123581
Ensembl:
ENSG00000177076
KO:
hsa:340485
|
| Nucleutide sequences |
EMBL-CDS:
AAH92487.1,
AAQ85132.1,
AAQ15241.1,
BAG53917.1
Gene_ORFName:
PP11646
Ensembl_TRS:
ENST00000340967
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000342609
RefSeq:
NP_001010887.2,
XP_011516160.1,
XP_011516161.1,
XP_005251505.1,
XP_016870183.1
|
| Others |
UniRef100:
UniRef100_Q5QJU3,
UniRef100_B3KVV5
UniRef90:
UniRef90_Q5QJU3
UniRef50:
UniRef50_Q5QJU3
UniGene:
Hs.41379
CCDS:
CCDS34992.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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