Transcription factor Foxp3 and its protein partners form a complex regulatory network.
[No authors listed]
摘要
The transcription factor Foxp3 is indispensible for the differentiation and function of regulatory T cells (T(reg) cells). To gain insights into the molecular mechanisms of Foxp3-mediated gene expression, we purified Foxp3 complexes and explored their composition. Biochemical and mass-spectrometric analyses revealed that Foxp3 forms multiprotein complexes of 400-800 kDa or larger and identified 361 associated proteins, â¼30% of which were transcription related. Foxp3 directly regulated expression of a large proportion of the genes encoding its cofactors. Some transcription factor partners of Foxp3 facilitated its expression. Functional analysis of the cooperation of Foxp3 with one such partner, GATA-3, provided additional evidence for a network of transcriptional regulation afforded by Foxp3 and its associates to control distinct aspects of T(reg) cell biology.
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基因功能
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基因
Ldlrap1, Kifc1, Noc4l, Acacb, Papd4, Rrp8, Clk3, Csnk1d, Tsr1, Utp15, Nckap1l, Lpxn, Whsc1, Chd4, Bre, Camk2d, Foxp1, Nusap1, Sp110, Rap1a, Sec13, Rps6ka3, Cse1l, Pwp2, Lims1, Add1, Adsl, Akp3, Ap1b1, Ap2a1, Ap3s1, Arpc1b, Atm, Bax, Bcl7c, Bop1, Runx1, Cbfb, Cbx4, Cct4, Cd2ap, Cdk11b, Cdk6, Cebpz, Coro1a, Coil, Dbnl, Dbt, Dync1h1, Dnm2, Ddx19a, Elf1, Mark2, Ercc3, Igf2bp3, Fasn, Fen1, Gata3, Nr3c1, Gspt1, H1f0, Hdac2, Hdac3, H2afx, Hk2, Hnrnpl, Inpp5d, Kif11, Kif4, Kpna3, Lat, Arhgef1, Lig3, Nup155, Pfkfb3, Max, Mllt10, Msh6, Map4, Myef2, Nfatc2, Ints6, Zfp638, Npm3, Orc1, Orc2, Pcx, Pdcd4, Pdcd6ip, Pfkl, Plec, Plk1, Lcp1, Pold1, Nup88, Prpf4b, Psme3, Slu7, Qk, Rac2, Rad21, Rad51, Ranbp2, Dpf2, Rnps1, Polr2a, Rrm2, Sap18, Atxn2, Foxp3, Smarca4, Smarcc1, Snrnp70, Bptf, Strbp, Dhx37, Stat3, Eif4g1, Rbmx2, Sirt7, Strap, Mapre2, Phf3, Rbbp5, Ythdf2, Tbl3, Arcn1, Kri1, Traf3ip3, Alyref, Nol10, Baz1a, Sipa1l1, Rcor1, Cdca7l, Heatr1, Tial1, Sec24c, Tln1, Haus4, Ska3, Ccar2, Tdrd3, Top1, Trp53, Tuba1c, Ube2m, Ufd1l, Vav1, Vezf1, Wiz, Wac, Wdr36, Taf6l, Yy1, Dars, Zfp148, Ahctf1, Ppp2r5a, Rexo4, Nup214, Gsn, Ikzf1, Ikzf3, Ppig, Gmps, Isg20l2, Ints3, Rsbn1, Rbm15, Gtf2b, Ptbp3, Gnl2, Fam76a, Eif4g3, Gcn1l1, Dera, Cnot3, Leng8, Gtf3c1, Ino80e, Whsc1l1, Gatad2a, Ddx49, Topbp1, Dync1li1, Gas2l3, Atad5, Coro1c, Arih1, Ash2l, Elmsan1, Irf2bpl, Tnpo1, Fyb, Dnajb6, Ik, Kif20b, Wdr76, Zfp771, Atr, Map7d1, Tubgcp3, Map2k1, Map2k2, Map2k7, Git2, Cul3, Ccnb1, Zfp346, Wdr3, Vcp, Zfp512, Aak1, Brd7, Etv3, Taf1, Add3, Rrp9, Imp4, Exosc5, Gtse1, Iqgap1, Med19, Trim56, Specc1, Hdac1, Acsl4, Orc3, Copb2, Srrm1, Ctps, Rif1, Knstrn, Rbm34, Ddx56, Suz12, Ncaph2, Plrg1, Snrpa, Prrc2a, Nudt5, Copg2, Zfp326, Phc2, Ncapg, Tfip11, Ppie, Uso1, Ftsj3, Mad2l1, Acin1, Patz1, Anapc7, Aatf, Adar, Elf4, Gsk3b, Mbnl1, Zbtb33, Park7, Smarce1, Noc2l, Fmnl1, Bcl11b, Rbm8a, Fam129a, Utp3, Ppil2, 1110037F02Rik, Dmap1, Dpy30, 2310022A10Rik, Nosip, Exosc7, Rps19bp1, Exosc1, Gpatch4, Sltm, Srp72, Nacc1, Ncbp3, Luc7l, Paics, Lrrc40, Nde1, Eif2s2, Ccdc137, Xab2, Chd8, Mak16, Fbxo28, Mphosph10, Chd1l, Gltscr2, Smarcc2, Fam98b, Rbm28, Rpa1, Prpf6, Gtpbp4, Ddx51, Cad, Fyttd1, Mcm10, Cd2bp2, Gtf3c5, Copb1, Sugp1, Zcchc8, Ints10, Cdc5l, Gtf3c2, Ap2b1, Cnn3, Aplf, Dhx36, Scaf11, Ssbp3, Utp14a, Bclaf1, Hnrnpll, Fam98a, Dhx30, Ddx41, Arhgef6, Thoc3, Wdr75, Dnm1l, Msl1, Rbm19, Foxp4, Sash3, Gtf2e1, Tubgcp2, Wdr33, Smchd1, Sf3a3, Nop14, Sgf29, Ckap5, Ncapg2, Las1l, Ppp1r18, Clasp2, Arfgap2, Bcl7a, Nkrf, Helz, Sp2, Krit1, Senp3, Tbl1xr1, Rbm5, Cenpq, Arid1a, Smarca5, Med15, Nol12, Trmt1l, Kdm1a
原始数据
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文献解读
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