| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 2, subunit 2 (beta) |
| Date | Results | Publications |
|---|---|---|
| 2017-08-19 11:36:00 | This study provides evidence that even a mild mutation in eIF2B, leading merely to a ~ 20% decrease in its enzymatic activity, is associated with mitochondrial malfunction caused by defective oxphos and with increased mitochondrial biogenesis compensating for energetic needs. | 28306143 |
| 2017-08-05 10:09:00 | GCN2 activation increased phosphorylation of its substrate eIF2alpha and the induction of the integrated stress response master regulator, ATF4. | 27852836 |
| 2015-01-17 10:50:00 | BMP-2 stimulates differentiation of myoblasts into osteoblasts via the PERK-eIF2alpha-ATF4 pathway but in addition stimulates Tmem119, which itself increases ATF4 | 24362451 |
| 2014-03-15 10:41:00 | This study extends our understanding of the roles played by GCN1 in GCN2 activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha kinase. | 24333428 |
| 2010-01-21 00:00:00 | Study found that the incidence of testicular germ cell tumor in affected males was reduced 2-fold in mice that were partially deficient for Eif2s2 and embryonic lethality occurred near the time of implantation in mice that were fully deficient for Eif2s2. | 19168544 |
| Type | IDs |
|---|---|
| Synonymous | 2810026E11Rik, 38kDa, AA408636, AA571381, AA986487, AW822225, D2Ertd303e, EIF2, EIF2B |
| Gene |
UniProtKB-ID:
IF2B_MOUSE,
Q3ULL5_MOUSE
UniprotKB:
Q99L45,
Q3ULL5
UniParc:
UPI0000027B96
EMBL:
AK145434,
AK145401,
AK166862,
BC113766,
AK012817,
BC003848,
AK011503
Ensembl:
ENSMUSG00000074656
KO:
mmu:67204
|
| Nucleutide sequences |
EMBL-CDS:
BAB27663.1,
AAH03848.1,
BAB28490.2,
BAE26433.1,
BAE39077.1,
BAE26414.1,
AAI13767.1
Ensembl_TRS:
ENSMUST00000099173,
ENSMUST00000166171
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000128257,
ENSMUSP00000096777
RefSeq:
NP_080306.1
|
| Others |
UniRef100:
UniRef100_Q99L45
UniRef90:
UniRef90_Q99L45
UniRef50:
UniRef50_P20042
UniGene:
Mm.377134,
Mm.470088
CCDS:
CCDS38292.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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