| Type | Description |
|---|---|
| Definition | linker for activation of T cells |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:59:00 | LRCH1 deficiency enhances LAT signalosome formation and CD8(+) T cell responses against tumors and pathogens. | 32727906 |
| 2020-09-19 16:26:00 | mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse. | 31911947 |
| 2020-04-04 12:18:00 | Study shows that tyrosine phosphorylation of the T cell adapter protein LAT at position Y132 is a critical kinetic bottleneck for ligand discrimination. The slow phosphorylation of Y132 is governed by a preceding glycine residue (G131) but can be accelerated by substituting this glycine with aspartate or glutamate. Slow phosphorylation of Y132 acts as a proofreading step to facilitate T cell ligand discrimination. | 31611699 |
| 2019-12-07 11:04:00 | These data enabled the identification of a negative regulation function for 4.1R in CD8(+) T cells by a direct association between 4.1R and LAT, possibly through inhibiting phosphorylation of LAT and then modulating intracellular signal transduction. | 31135971 |
| 2019-06-22 11:51:00 | LAT, once internalized, transits through the Golgi-trans-Golgi network (TGN), where it is repolarized to the immune synapse. | 29440364 |
| Type | IDs |
|---|---|
| Synonymous | p36-38, pp36 |
| Gene |
UniProtKB-ID:
LAT_MOUSE,
Q546H1_MOUSE,
A0A0U1RP03_MOUSE
UniprotKB:
O54957,
Q546H1,
A0A0U1RP03
UniParc:
UPI000000158B,
UPI0005AB9F2A
EMBL:
AC125322,
AK134003,
AF036907,
BC013337,
AJ438435
Ensembl:
ENSMUSG00000030742
KO:
mmu:16797
|
| Nucleutide sequences |
EMBL-CDS:
AAC40054.1,
AAH13337.1,
BAE21976.1,
CAD27390.1
Ensembl_TRS:
ENSMUST00000032997,
ENSMUST00000206793
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000032997,
ENSMUSP00000145773
RefSeq:
XP_006507461.1,
XP_030098032.1,
XP_006507460.2,
NP_034819.1,
XP_006507459.3
|
| Others |
UniRef100:
UniRef100_A0A0U1RP03,
UniRef100_O54957
UniRef90:
UniRef90_A0A0U1RP03,
UniRef90_O54957
UniRef50:
UniRef50_A0A0U1RP03,
UniRef50_O54957
UniGene:
Mm.10280
CCDS:
CCDS21825.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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