| Type | Description |
|---|---|
| Definition | FYN binding protein |
| Date | Results | Publications |
|---|---|---|
| 2020-02-05 12:26:00 | Results demonstrated that loss of ADAP restricted to the megakaryocytic lineage, has no impact on other hematopoietic cells, causes thrombocytopenia and reduced plasma levels of PF4 and TGF-beta1, impairs CLEC-2-mediated platelet activation in vitro, and results in enhanced experimental autoimmune encephalomyelitis severity. | 30833485 |
| 2019-07-20 11:39:00 | Adap(-/-) mice have moderate thrombocytopenia and smaller platelets. Adap(-/-) platelets had a shorter life span than controlss. Cultured ADAP(-) BM-derived MKs had reduced spreading on extracellular matrix proteins and beta1 integrin activation, impaired podosome formation, and defective polarization of the demarcation membrane system. ADAP has an unspecified role in the process of MK polarization and platelet biogene... | 29950291 |
| 2017-09-09 14:20:00 | ADAP fulfills different functions in CD4(+) and CD8(+) T cells, with CD8(+) T cells being less dependent on ADAP. | 27605210 |
| 2017-08-12 10:14:00 | ADAP regulates CD8 T cell differentiation events following acute pathogen challenge that are critical for the formation and selected functions of TRM cells in nonlymphoid tissues. | 27521337 |
| 2016-04-02 10:49:00 | Data (including data from studies in knockout/transgenic mice) suggest that ADAP regulates positive feedback loop of TGFbeta1 production and TGFbeta1-induced CD103 expression in CD8+ T-lymphocytes and protects against influenza H5N1 virus infection. | 25909459 |
| Type | IDs |
|---|---|
| Synonymous | ADAP, B630013F22Rik, FYB-120/130, Fyb1, Slap130, p120/130, p120/p130 |
| Gene |
UniProtKB-ID:
FYB1_MOUSE,
B2RUR0_MOUSE
UniprotKB:
O35601,
B2RUR0
UniParc:
UPI00000299B9,
UPI000002AA18
EMBL:
AF001863,
AF061744,
BC141352
Ensembl:
ENSMUSG00000022148
KO:
mmu:23880
|
| Nucleutide sequences |
EMBL-CDS:
AAD03267.1,
AAB62227.1,
AAI41353.1
Ensembl_TRS:
ENSMUST00000090461
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000087947
RefSeq:
XP_006520049.1,
XP_011243630.1,
XP_036015282.1,
XP_006520046.1,
NP_001265198.1,
NP_035945.1,
XP_006520045.1,
XP_006520048.1,
XP_011243631.1
|
| Others |
UniRef100:
UniRef100_O35601
UniRef90:
UniRef90_O35601
UniRef50:
UniRef50_O35601
UniGene:
Mm.170905
CCDS:
CCDS37031.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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