| Type | Description |
|---|---|
| Definition | topoisomerase (DNA) I |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 12:09:00 | Topoisomerase 1 (TOP1) conditionally deleted neurons develop properly, but then show biased transcriptional downregulation of long genes, signs of DNA damage, neuroinflammation, increased poly(ADP-ribose) polymerase-1 activity, single-cell somatic mutations, and ultimately degeneration. While neurodegeneration is partially rescued by supplementations, behavioral decline is not prevented. | 32327659 |
| 2017-09-23 13:38:00 | treatment of topotecan, a brain-penetrating topoisomerase 1 inhibitor, to HD transgenic mouse considerably improved its motor behavioural abnormalities. Finally, we show that topotecan treatment to HD mouse not only inhibits the expression of transgenic mutant huntingtin, but also at the same time induces the expression of Ube3a | 28007908 |
| 2017-09-09 11:03:00 | It has been shown that the livers of Sprtn deficient mice accumulate DNA-protein crosslinks containing Topoisomerase 1 covalently linked to DNA. | 28199696 |
| 2017-07-22 13:17:00 | TOP1cc-dependent and -independent contributions to gene expression | 27231886 |
| 2017-07-01 10:36:00 | this study identified topoisomerase 1 as a cardinal Aire partner that colocalized on super-enhancers and was required for the interaction of Aire with all of its other associates | 28135252 |
| Type | IDs |
|---|---|
| Synonymous | AI467334, D130064I21Rik, Top-1 |
| Gene |
UniProtKB-ID:
TOP1_MOUSE,
Q3TPX7_MOUSE,
Q3ULF5_MOUSE
UniprotKB:
Q04750,
Q3TPX7,
Q3ULF5
UniParc:
UPI00005AC43A,
UPI00001EE4C4,
UPI00005B2013
EMBL:
AK164061,
L20632,
AL590414,
AK145538,
D10061,
AL591673
Ensembl:
ENSMUSG00000070544
KO:
mmu:21969
|
| Nucleutide sequences |
EMBL-CDS:
CAM25349.1,
AAA40466.1,
BAA00950.1,
CAM20297.1,
BAE37608.1,
BAE26493.1
Ensembl_TRS:
ENSMUST00000109468
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000105094
RefSeq:
NP_033434.2
|
| Others |
UniRef100:
UniRef100_Q3ULF5,
UniRef100_Q04750
UniRef90:
UniRef90_Q3ULF5,
UniRef90_Q9WUL0
UniRef50:
UniRef50_Q3ULF5,
UniRef50_P11387
UniGene:
Mm.217233
CCDS:
CCDS16995.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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