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52615 Suz12

52615

Suz12

SUZ12 polycomb repressive complex 2 subunit

protein-coding

Mus musculus

基因描述

Type Description
Definition SUZ12 polycomb repressive complex 2 subunit

研究结论

Date Results Publications
2020-02-08 10:58:00 Here we show that CRISPR/Cas9-mediated inactivation of Suz12 cooperates with mutant JAK3 to drive T-cell transformation and T-cell acute lymphoblastic leukemia development 31492675
2019-07-27 11:15:00 SUZ12 binds to CpG islands and this stable recruitment to genomic loci is essential for correct H3K27 methylation patterns. 29483650
2019-02-09 10:56:00 Nsd1 is a key modulator of PRC2 function required for regulating the demarcation of genome-wide H3K27me2 and H3K27me3 domains in embryonic stem cells. 29606589
2017-11-25 14:40:00 we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes 27150236
2017-10-28 11:29:00 Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and reduce PRC2 chromatin engagement. 29033324

名称对应

Type IDs
Synonymous 2610028O16Rik, AI195385, AU016842, AW536442, D11Ertd530e, mKIAA0160
Gene
UniProtKB-ID: SUZ12_MOUSE, E9PW15_MOUSE
UniprotKB: Q80U70, E9PW15
UniParc: UPI00001B2F55, UPI0001AE8268
EMBL: BC051099, AK122213, AL591113, BC064461, BC003922
Ensembl: ENSMUSG00000017548
KO: mmu:52615
Nucleutide sequences
EMBL-CDS: AAH03922.1, AAH51099.1, BAC65495.1, AAH64461.1
Ensembl_TRS: ENSMUST00000017692, ENSMUST00000163272
Protein sequencees
Ensembl_PRO: ENSMUSP00000017692, ENSMUSP00000126932
RefSeq: NP_954666.1, NP_001156490.1
Others
UniRef100: UniRef100_Q80U70, UniRef100_E9PW15
UniRef90: UniRef90_Q80U70, UniRef90_J3QQW9
UniRef50: UniRef50_Q80U70, UniRef50_Q6DC03
UniGene: Mm.283410, Mm.473315
CCDS: CCDS25125.1

全选

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