| Type | Description |
|---|---|
| Definition | Sp110 nuclear body protein |
| Date | Results | Publications |
|---|---|---|
| 2017-08-05 11:05:00 | mechanistic studies revealed that an arginine/lysine-rich element within the DNA-binding domain (SAND domain) is critical for Ipr1 binding to the importin protein receptor NPI-1, demonstrating that this element plays an essential role in mediating the nuclear localization of Ipr1 protein | 27622275 |
| 2017-08-05 10:11:00 | Using mouse models and genetic characteristics of human patients the role of SP110b was studied to determine its role in controlling host immunity and susceptibility to TB by modulating nuclear factor-kappaB (NF-kappaB) activity resulting in down regulation of TNF-alpha production and upregulation of NF-kappaB-induced antipoptotic gene expression suppressing IFN-gamma-mediated monocyte and/or macrophage cell death. | 27858493 |
| 2016-12-24 10:48:00 | These findings not only reveal the transcriptional basis of Sp110-mediated macrophage resistance to Mtb, but also suggest potential regulatory roles for Sp110 related to inflammatory responses, miRNA profiles, and the intracellular growth of Mtb. | 26912204 |
| 2016-11-12 11:40:00 | strain-specific promoter region polymorphism is associated with resistance to tuberculosis | 26590945 |
| 2011-11-26 11:25:00 | mediates RAW 264.7 macrophage cell line resistance to Mycobacterium bovis | 21790702 |
| Type | IDs |
|---|---|
| Synonymous | 5031415C07Rik, 52kDa, 5830484A20Rik, Ifi75, Ipr1 |
| Gene |
UniProtKB-ID:
SP110_MOUSE
UniprotKB:
Q8BVK9
UniParc:
UPI00000EA8D4
EMBL:
BC094500,
BC039938,
AY845948,
AK150373,
BC018413,
AK077800
Ensembl:
ENSMUSG00000070034
KO:
mmu:109032
|
| Nucleutide sequences |
EMBL-CDS:
AAH39938.1,
BAC37018.1,
AAH18413.1,
AAH94500.1,
BAE29505.1,
AAW32543.1
Ensembl_TRS:
ENSMUST00000093508
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000091226
RefSeq:
XP_011246200.1,
XP_030111545.1,
NP_780606.3,
XP_011246202.1,
XP_011246203.1,
NP_084470.1,
XP_006529132.1,
XP_011246201.1,
XP_011246199.1
|
| Others |
UniRef100:
UniRef100_Q8BVK9
UniRef90:
UniRef90_Q8BVK9
UniRef50:
UniRef50_Q8BVK9
UniGene:
Mm.335802,
Mm.461913
CCDS:
CCDS35637.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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