| Type | Description |
|---|---|
| Definition | IKAROS family zinc finger 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-12 14:43:00 | deletion of the E120 enhancer resulted in a significant reduction of Ikzf1 mRNA. However, the epigenetic landscape and 3D topology of the locus were only slightly affected, highlighting the complexity of the regulatory landscape regulating the Ikzf1 locus. | 32453736 |
| 2020-06-06 11:51:00 | Ikaros and Ikaros-induced enhancers are responsible for the cessation of proliferation and induction of T-cell differentiation in T-ALL cells | 31073152 |
| 2020-05-30 10:46:00 | altered Ikaros expression in chronic lymphocytic leukemia or radioresistant B-1 cells could determine a responsive status of BCR to self-antigens, which would culminate in the clonal expansion of B-1 cells. | 31299112 |
| 2020-04-04 11:31:00 | Study demonstrated that the loss of Ikaros causes systemic autoimmunity in a mouse model with selective inactivation of Ikzf1 in B cells. Detailed molecular analyses revealed that Ikaros suppresses autoimmunity by inducing B cell antigen receptor anergy and restraining TLR signaling in autoreactive B cells. | 31591571 |
| 2019-10-26 11:03:00 | The data definitively define Ikaros as a critical regulator at the center of the inflammatory response in T cells and highlight a potential role in suppressing autoimmunity. | 30635395 |
| Type | IDs |
|---|---|
| Synonymous | 5832432G11Rik, Ikaros, LyF-1, Zfpn1a1, Znfn1a1, hlk-1, mKIAA4227 |
| Gene |
UniProtKB-ID:
Q5SWU0_MOUSE,
Q3UQ33_MOUSE,
Q8C9X3_MOUSE,
Q8C5P6_MOUSE,
Q5SWT9_MOUSE,
G5E8H3_MOUSE
UniprotKB:
Q5SWU0,
Q3UQ33,
Q8C9X3,
Q8C5P6,
Q5SWT9,
G5E8H3
UniParc:
UPI0000021617,
UPI00000E9C37,
UPI00005AC185,
UPI00000E96CD,
UPI000047048F,
UPI0000026A5A
EMBL:
AL596450,
AK077815,
AK142856,
BC138789,
AK040268
Ensembl:
ENSMUSG00000018654
KO:
mmu:22778
|
| Nucleutide sequences |
EMBL-CDS:
AAI38790.1,
BAE25211.1,
BAC30556.1,
BAC37022.1
Ensembl_TRS:
ENSMUST00000018798,
ENSMUST00000048122,
ENSMUST00000065433,
ENSMUST00000076700
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000018798,
ENSMUSP00000046974,
ENSMUSP00000067372,
ENSMUSP00000075992
RefSeq:
NP_001288795.1,
XP_030101813.1,
XP_006514745.1,
XP_011242017.1,
XP_011242007.1,
NP_001288797.1,
XP_006514743.1,
XP_011242020.1,
XP_011242016.1,
XP_011242002.1,
XP_011242018.1,
XP_011242006.1,
XP_011242019.1,
XP_011242009.1,
XP_011242010.1,
XP_011242008.1,
NP_001288792.1,
XP_011242014.1,
XP_011242004.1,
XP_011242005.1,
XP_011242015.1,
XP_011242011.1,
NP_001288794.1,
XP_006514739.1,
XP_011242003.1,
NP_033604.2,
NP_001020768.1,
XP_011242012.1,
XP_011242013.1
|
| Others |
UniRef100:
UniRef100_Q5SWU0,
UniRef100_Q5SWT9,
UniRef100_Q3UQ33,
UniRef100_G5E8H3,
UniRef100_Q8C9X3,
UniRef100_Q8C5P6
UniRef90:
UniRef90_Q8C9X3,
UniRef90_Q8C5P6,
UniRef90_Q03267-6,
UniRef90_Q03267
UniRef50:
UniRef50_Q13422,
UniRef50_Q13422-8,
UniRef50_Q03267-6,
UniRef50_Q8C9X3
UniGene:
Mm.103545
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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