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72935 Ddx41

72935

Ddx41

DEAD (Asp-Glu-Ala-Asp) box polypeptide 41

protein-coding

Mus musculus

基因描述

Type Description
Definition DEAD (Asp-Glu-Ala-Asp) box polypeptide 41

研究结论

Date Results Publications
2019-03-02 10:56:00 Both DDX41 and cGAS are needed for the antiretroviral innate immune response to murine leukemia virus (MLV) and HIV in primary mouse macrophages and dendritic cells. 29871919
2015-12-05 10:31:00 Tyr364 and Tyr414 of DDX41 are critical for its recognition of AT-rich DNA and binding to STING, and tandem mass spectrometry identifies Tyr414 as the BTK phosphorylation site. 25704810
2013-03-09 10:08:00 TRIM21 is an interferon-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 and negatively regulates the innate immune response to intracellular double-stranded DNA. 23222971
2011-11-26 10:35:00 DDX41 is an additional DNA sensor that depends on STING to sense pathogenic DNA. 21892174

名称对应

Type IDs
Synonymous 2900024F02Rik, AA958953, ABS, AI324246
Gene
UniProtKB-ID: DDX41_MOUSE, Q9CUY2_MOUSE, Q3UAC4_MOUSE
UniprotKB: Q91VN6, Q9CUY2, Q3UAC4
UniParc: UPI00005ACAEF, UPI00000E7820, UPI00001E8341
EMBL: AK151427, BC011308, AK013586, AK156957
Ensembl: ENSMUSG00000021494
KO: mmu:72935
Nucleutide sequences
EMBL-CDS: AAH11308.1, BAE33914.1, BAB28917.1, BAE30391.1
Ensembl_TRS: ENSMUST00000021956
Protein sequencees
Ensembl_PRO: ENSMUSP00000021956
RefSeq: NP_598820.2, XP_030103292.1
Others
UniRef100: UniRef100_Q3UAC4, UniRef100_Q91VN6
UniRef90: UniRef90_Q91VN6, UniRef90_Q9UJV9
UniRef50: UniRef50_Q9UJV9
UniGene: Mm.205045
CCDS: CCDS26549.1

全选

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