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79264 Krit1

79264

Krit1

KRIT1, ankyrin repeat containing

protein-coding

Mus musculus

基因描述

Type Description
Definition KRIT1, ankyrin repeat containing

研究结论

Date Results Publications
2020-02-15 10:04:00 KRIT1 loss of function mutation causes aortic endothelial dysfunction. 31590384
2019-05-04 12:42:00 this study shows that KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress 29170092
2019-03-09 10:41:00 our data indicate that signaling is critical for the loss of barrier function following genetic deletion of KRIT1. 28811547
2017-12-09 10:33:00 Data show that the reduced expression of thrombospondin1 (TSP1) that follows Krit1 inactivation contributes to cavernous malformation (CCM) lesion pathogenesis. 28970240
2015-10-31 10:34:00 Lesions develop in a stereotypic location and pattern, preceded by endothelial hypersprouting as confirmed in a zebrafish model of disease. The vascular defects seen with loss of Ccm1 suggest a defect in endothelial flow response. 24990152

名称对应

Type IDs
Synonymous 2010007K12Rik, A630036P20Rik, AA432855, AI450393, AI643869, BB155247, BB235701, Ccm1
Gene
UniProtKB-ID: KRIT1_MOUSE, B2RUA8_MOUSE
UniprotKB: Q6S5J6, B2RUA8
UniParc: UPI0000225E2A, UPI0000225AD7, UPI00005B7376, UPI00001B2C6D
EMBL: AK041574, AF306509, AF310134, BC141042, BC054819, AY328895, AY464945
Ensembl: ENSMUSG00000000600
KO: mmu:79264
Nucleutide sequences
EMBL-CDS: AAG47775.1, AAG18456.1, AAH54819.1, BAC30991.1, AAQ92980.1, AAR24089.1, AAI41043.1
Ensembl_TRS: ENSMUST00000080085, ENSMUST00000200577, ENSMUST00000171023
Protein sequencees
Ensembl_PRO: ENSMUSP00000132375, ENSMUSP00000078985, ENSMUSP00000143776
RefSeq: NP_109600.2, NP_001164023.1, XP_006503680.1, XP_030110771.1, XP_030110772.1, XP_006503681.1
Others
UniRef100: UniRef100_Q6S5J6
UniRef90: UniRef90_O00522
UniRef50: UniRef50_O00522
UniGene: Mm.32368, Mm.482273
CCDS: CCDS39002.1, CCDS51409.1

全选

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