| Type | Description |
|---|---|
| Definition | KRIT1, ankyrin repeat containing |
| Date | Results | Publications |
|---|---|---|
| 2020-02-15 10:04:00 | KRIT1 loss of function mutation causes aortic endothelial dysfunction. | 31590384 |
| 2019-05-04 12:42:00 | this study shows that KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress | 29170092 |
| 2019-03-09 10:41:00 | our data indicate that signaling is critical for the loss of barrier function following genetic deletion of KRIT1. | 28811547 |
| 2017-12-09 10:33:00 | Data show that the reduced expression of thrombospondin1 (TSP1) that follows Krit1 inactivation contributes to cavernous malformation (CCM) lesion pathogenesis. | 28970240 |
| 2015-10-31 10:34:00 | Lesions develop in a stereotypic location and pattern, preceded by endothelial hypersprouting as confirmed in a zebrafish model of disease. The vascular defects seen with loss of Ccm1 suggest a defect in endothelial flow response. | 24990152 |
| Type | IDs |
|---|---|
| Synonymous | 2010007K12Rik, A630036P20Rik, AA432855, AI450393, AI643869, BB155247, BB235701, Ccm1 |
| Gene |
UniProtKB-ID:
KRIT1_MOUSE,
B2RUA8_MOUSE
UniprotKB:
Q6S5J6,
B2RUA8
UniParc:
UPI0000225E2A,
UPI0000225AD7,
UPI00005B7376,
UPI00001B2C6D
EMBL:
AK041574,
AF306509,
AF310134,
BC141042,
BC054819,
AY328895,
AY464945
Ensembl:
ENSMUSG00000000600
KO:
mmu:79264
|
| Nucleutide sequences |
EMBL-CDS:
AAG47775.1,
AAG18456.1,
AAH54819.1,
BAC30991.1,
AAQ92980.1,
AAR24089.1,
AAI41043.1
Ensembl_TRS:
ENSMUST00000080085,
ENSMUST00000200577,
ENSMUST00000171023
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000132375,
ENSMUSP00000078985,
ENSMUSP00000143776
RefSeq:
NP_109600.2,
NP_001164023.1,
XP_006503680.1,
XP_030110771.1,
XP_030110772.1,
XP_006503681.1
|
| Others |
UniRef100:
UniRef100_Q6S5J6
UniRef90:
UniRef90_O00522
UniRef50:
UniRef50_O00522
UniGene:
Mm.32368,
Mm.482273
CCDS:
CCDS39002.1,
CCDS51409.1
|