| Type | Description |
|---|---|
| Definition | flap structure specific endonuclease 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-08-03 12:23:00 | Kinetic measurements showed that the active site mutants A159V and E160D reduce the rates of hydrolysis under multiple- and single-turnover conditions on all substrates. Consistent with their dominant negative effects in heterozygotes, neither mutation affects the adoption of the substrate duplex arms in the bent conformation on the enzyme surface, although decreases in substrate binding affinity are observed. | 30472848 |
| 2017-09-02 12:53:00 | These results reveal an important role of FEN1 phosphorylation to counteract oxygen-induced stress in the heart during the fetal-to-neonatal transition. | 27694478 |
| 2016-06-11 10:52:00 | WDR4 regulates FEN1's potential DNA cleavage threat near the site of replication. | 26751069 |
| 2015-04-11 12:16:00 | The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers. | 24608430 |
| 2012-12-29 11:12:00 | is required for FEN1 recruitment to DNA repair intermediates in base excision repair. | 22810208 |
| Type | IDs |
|---|---|
| Synonymous | AW538437, FEN-1 |
| Gene |
UniProtKB-ID:
Q91Z50_MOUSE,
Q8C952_MOUSE
UniprotKB:
Q91Z50,
Q8C952
UniParc:
UPI0000022418,
UPI00000E97CF
EMBL:
AK046256,
AK153889,
AB191468,
AK166948,
AK078778,
AC132148,
BC010203,
AK042942,
AK161047
Ensembl:
ENSMUSG00000024742
KO:
mmu:14156
|
| Nucleutide sequences |
EMBL-CDS:
BAE36169.1,
BAD52443.1,
BAE39135.1,
BAC32660.1,
BAC37390.1,
BAE32236.1,
AAH10203.1,
BAC31412.1
Ensembl_TRS:
ENSMUST00000142241,
ENSMUST00000116542,
ENSMUST00000156291,
ENSMUST00000025651
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000117246,
ENSMUSP00000119221,
ENSMUSP00000112241,
ENSMUSP00000025651
RefSeq:
NP_001258543.1,
XP_006526727.1,
NP_001258544.1,
XP_006526724.1,
XP_006526726.1,
NP_032025.2
|
| Others |
UniRef100:
UniRef100_Q8C5X6,
UniRef100_Q8C952
UniRef90:
UniRef90_P39749
UniRef50:
UniRef50_P39748
UniGene:
Mm.2952
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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