| Type | Description |
|---|---|
| Definition | topoisomerase (DNA) II binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-14 12:33:00 | TopBP1 deficiency during spermatogenesis impairs the localization of proteins involved in early recombination at DNA double-strand break, results in meiotic chromosome defects and leads to infertility. | 30528234 |
| 2018-06-30 11:54:00 | DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line. | 29114052 |
| 2015-06-27 12:34:00 | Consistent with prior reports, TopBP1 co-localized in discrete nuclear foci and was in complex with papillomavirus E2 protein. | 25666521 |
| 2015-06-27 12:04:00 | The deacetylated form of TopBP1 in SIRT1 mutant cells repressed replication origin firing, while the acetylated form of TopBP1 lost this function. | 25516717 |
| 2015-02-07 12:12:00 | Studies identify the SIRT1-TopBP1 axis as a key signaling mode in the regulation of the metabolic checkpoint and the DNA damage checkpoint. | 25454945 |
| Type | IDs |
|---|---|
| Synonymous | 1110031N14Rik, 2810429C13Rik, AI256758, D430026L04Rik, mKIAA0259 |
| Gene |
UniProtKB-ID:
TOPB1_MOUSE
UniprotKB:
Q6ZQF0
UniParc:
UPI000017D9EB
EMBL:
AK129104,
AK085031,
BC049797,
BC062111,
BC026608,
BC007170,
BC006707,
AK084654
Ensembl:
ENSMUSG00000032555
KO:
mmu:235559
|
| Nucleutide sequences |
EMBL-CDS:
BAC39241.2,
AAH06707.1,
AAH49797.1,
AAH62111.1,
AAH26608.1,
AAH07170.1,
BAC97914.1,
BAC39345.1
Ensembl_TRS:
ENSMUST00000035164
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000035164
RefSeq:
XP_006511770.1,
NP_795953.2,
XP_006511769.3
|
| Others |
UniRef100:
UniRef100_Q6ZQF0
UniRef90:
UniRef90_Q6ZQF0
UniRef50:
UniRef50_Q92547
UniGene:
Mm.259893
CCDS:
CCDS23453.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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