| Type | Description |
|---|---|
| Definition | polymerase (DNA directed), delta 1, catalytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2012-11-24 11:13:00 | reducing expression of individual PRMT7 target DNA repair genes showed that only the catalytic subunit of DNA polymerase, POLD1, was able to resensitize PRMT7 knock-down cells to DNA-damaging agents. | 22761421 |
| 2010-01-21 12:47:00 | Findings distinguish Pol epsilon and delta functions in vivo and reveal tissue-specific requirements for DNA replication fidelity. | 19805137 |
| 2010-01-21 00:00:00 | A point mutation (D400A) in the proofreading domain of DNA polymerase delta, encoded by the Pold1 gene, inactivates the 3' --> 5' exonuclease of poldelta and causes a mutator and epithelial cancer phenotype in a recessive manner. | 12429860 |
| 2010-01-21 00:00:00 | DNA polymerase delta is essential for mammalian early embryogenesis, and the 3'-5' exonuclease activity of DNA polymerase delta is dispensable for normal development but necessary to suppress tumorigenesis | 19145245 |
| 2010-01-21 00:00:00 | Heterozygous mutation at L604 in the polymerase active site of DNA polymerase delta reduces life span, increases genomic instability, and accelerates tumorigenesis in an allele-specific manner, novel findings that have implications for human cancer. | 17785453 |
| Type | IDs |
|---|---|
| Synonymous | 125kDa |
| Gene |
UniProtKB-ID:
DPOD1_MOUSE
UniprotKB:
P52431
UniParc:
UPI0000026ED9
EMBL:
AK169040,
AF024570,
Z21848,
AK167569,
AK168967
Ensembl:
ENSMUSG00000038644
KO:
mmu:18971
|
| Nucleutide sequences |
EMBL-CDS:
CAA79895.1,
AAB99910.1,
BAE39632.1,
BAE40829.1,
BAE40772.1
Ensembl_TRS:
ENSMUST00000049343
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000039776
RefSeq:
XP_030098080.1,
NP_035261.3
|
| Others |
UniRef100:
UniRef100_P52431
UniRef90:
UniRef90_P52431
UniRef50:
UniRef50_P52431
UniGene:
Mm.16549
CCDS:
CCDS21210.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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