| Type | Description |
|---|---|
| Definition | ligase III, DNA, ATP-dependent |
| Date | Results | Publications |
|---|---|---|
| 2017-11-26 00:16:00 | Telomere-internal double-strand breaks (DSBs) are also repaired by a and Ligase3-dependent reaction, suggesting alternative non-homologous end-joining (alt-NHEJ), which relies on microhomology at DSBs. | 27806302 |
| 2014-11-22 13:02:00 | Results show that overexpression of DNA ligase III in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress. | 24674627 |
| 2014-07-26 11:20:00 | data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM in regulating DNA Lig3 stability and consequently mtDNA repair | 24342190 |
| 2013-12-21 11:42:00 | Lig3 has an essential role in mtDNA maintenance but is dispensable for the viability of cultured cells | 23884459 |
| 2011-03-26 10:23:00 | data reveal that the critical biological role of Lig3 is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair | 21390131 |
| Type | IDs |
|---|---|
| Synonymous | D11Wsu78e |
| Gene |
UniProtKB-ID:
Q80ZH7_MOUSE,
Q3UC82_MOUSE
UniprotKB:
Q80ZH7,
Q3UC82
UniParc:
UPI00005ACA0D,
UPI00000219D7
EMBL:
AK143531,
AK150644,
AL645594,
BC049240
Ensembl:
ENSMUSG00000020697
KO:
mmu:16882
|
| Nucleutide sequences |
EMBL-CDS:
BAE25421.1,
AAH49240.1,
BAE29732.1
Ensembl_TRS:
ENSMUST00000173722,
ENSMUST00000092849,
ENSMUST00000173347,
ENSMUST00000173727
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000133805,
ENSMUSP00000090525,
ENSMUSP00000134300,
ENSMUSP00000133849
RefSeq:
NP_001278175.1,
XP_006532413.1,
XP_006532411.1,
XP_006532410.1,
XP_006532416.1,
NP_001278174.1,
NP_001278176.1,
NP_034846.2
|
| Others |
UniRef100:
UniRef100_Q3UC82,
UniRef100_Q80ZH7
UniRef90:
UniRef90_P97386
UniRef50:
UniRef50_P49916
UniGene:
Mm.277136
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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