| Type | Description |
|---|---|
| Definition | SAM and SH3 domain containing 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-01 13:05:00 | In this report, the structure of the SLy1 SAM domain was solved and revealed that this SAM domain forms a symmetric homodimer through a novel interface. The interface consists primarily of the two long C-terminal helices, alpha5 and alpha5', of the domains packing against each other. | 30631134 |
| 2019-12-14 11:19:00 | We also carried out transgene rescue by adding Sly1/2 transgenes to mice with NPYq deletions. We demonstrated that SLY1/2 expression in mutant mice decreased proportionally to deletion size, with ~12% of SLY1/2 retained in shSLY sh367 testes. | 30759861 |
| 2016-04-16 10:50:00 | this study describes SLy1 as an immunoregulatory protein, which is involved in the generation of adaptive immune responses during L. monocytogenes infection, and provides a model of how SLy1 regulates T-cell proliferation. | 26306874 |
| 2010-01-21 00:00:00 | expression of the Notch signaling mediator RBP-J and the Notch target genes Hes-1 and Hes-5 was markedly reduced in MZ but not FO B cells of Sly1(d/d) mice. | 18950867 |
| 2010-01-21 00:00:00 | Sly1 is an essential molecular component for the full activation of adaptive immunity | 16227612 |
| Type | IDs |
|---|---|
| Synonymous | 1200013B08Rik, AW413946, SLY1 |
| Gene |
UniProtKB-ID:
SASH3_MOUSE
UniprotKB:
Q8K352
UniParc:
UPI000002369F
EMBL:
AK171017,
AK004734,
BC028773,
AJ306422,
AK156202
Ensembl:
ENSMUSG00000031101
KO:
mmu:74131
|
| Nucleutide sequences |
EMBL-CDS:
CAC67499.1,
AAH28773.1,
BAB23516.1,
BAE33623.1,
BAE42187.1
Ensembl_TRS:
ENSMUST00000033427
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033427
RefSeq:
NP_001300678.1,
NP_083049.1
|
| Others |
UniRef100:
UniRef100_Q8K352
UniRef90:
UniRef90_Q8K352
UniRef50:
UniRef50_Q8K352
UniGene:
Mm.276131
CCDS:
CCDS40959.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 30759861 |
Genes (Basel) Jonathan M Riel , Yasuhiro Yamauchi , Victor A Ruthig , Qushay U Malinta , Mélina Blanco , Charlotte Moretti , Julie Cocquet , Monika A Ward |
2019-02-12 | - |
| 30631134 |
Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association. Sci Rep Laura Kukuk , Andrew J Dingley , Joachim Granzin , Luitgard Nagel-Steger , Pallavi Thiagarajan-Rosenkranz , Daniel Ciupka , Karen Hänel , Renu Batra-Safferling , Victor Pacheco , Matthias Stoldt , Klaus Pfeffer , Sandra Beer-Hammer , Dieter Willbold , Bernd W Koenig |
2019-01-10 | - |
| 26306874 |
Eur. J. Immunol. Daniel Schäll , Fee Schmitt , Bernhard Reis , Simone Brandt , Sandra Beer-Hammer |
2015-11-01 |
Sash3
|
| 22922362 |
Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat. Immunol. Dipayan Rudra , Paul deRoos , Ashutosh Chaudhry , Rachel E Niec , Aaron Arvey , Robert M Samstein , Christina Leslie , Scott A Shaffer , David R Goodlett , Alexander Y Rudensky |
2012-10-01 |
Ldlrap1,
Kifc1,
Noc4l,
Acacb,
Papd4,
Rrp8,
Clk3,
Csnk1d,
Tsr1,
Utp15,
Nckap1l,
Lpxn,
Whsc1,
Chd4,
Bre,
Camk2d,
Foxp1,
Nusap1,
Sp110,
Rap1a,
Sec13,
Rps6ka3,
Cse1l,
Pwp2,
Lims1,
Add1,
Adsl,
Akp3,
Ap1b1,
Ap2a1,
Ap3s1,
Arpc1b,
Atm,
Bax,
Bcl7c,
Bop1,
Runx1,
Cbfb,
Cbx4,
Cct4,
Cd2ap,
Cdk11b,
Cdk6,
Cebpz,
Coro1a,
Coil,
Dbnl,
Dbt,
Dync1h1,
Dnm2,
Ddx19a,
Elf1,
Mark2,
Ercc3,
Igf2bp3,
Fasn,
Fen1,
Gata3,
Nr3c1,
Gspt1,
H1f0,
Hdac2,
Hdac3,
H2afx,
Hk2,
Hnrnpl,
Inpp5d,
Kif11,
Kif4,
Kpna3,
Lat,
Arhgef1,
Lig3,
Nup155,
Pfkfb3,
Max,
Mllt10,
Msh6,
Map4,
Myef2,
Nfatc2,
Ints6,
Zfp638,
Npm3,
Orc1,
Orc2,
Pcx,
Pdcd4,
Pdcd6ip,
Pfkl,
Plec,
Plk1,
Lcp1,
Pold1,
Nup88,
Prpf4b,
Psme3,
Slu7,
Qk
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21267068 |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. Graciana Diez-Roux , Sandro Banfi , Marc Sultan , Lars Geffers , Santosh Anand , David Rozado , Alon Magen , Elena Canidio , Massimiliano Pagani , Ivana Peluso , Nathalie Lin-Marq , Muriel Koch , Marchesa Bilio , Immacolata Cantiello , Roberta Verde , Cristian De Masi , Salvatore A Bianchi , Juliette Cicchini , Elodie Perroud , Shprese Mehmeti , Emilie Dagand , Sabine Schrinner , Asja Nürnberger , Katja Schmidt , Katja Metz , Christina Zwingmann , Norbert Brieske , Cindy Springer , Ana Martinez Hernandez , Sarah Herzog , Frauke Grabbe , Cornelia Sieverding , Barbara Fischer , Kathrin Schrader , Maren Brockmeyer , Sarah Dettmer , Christin Helbig , Violaine Alunni , Marie-Annick Battaini , Carole Mura , Charlotte N Henrichsen , Raquel Garcia-Lopez , Diego Echevarria , Eduardo Puelles , Elena Garcia-Calero , Stefan Kruse , Markus Uhr , Christine Kauck , Guangjie Feng , Nestor Milyaev , Chuang Kee Ong , Lalit Kumar , MeiSze Lam , Colin A Semple , Attila Gyenesei , Stefan Mundlos , Uwe Radelof , Hans Lehrach , Paolo Sarmientos , Alexandre Reymond , Duncan R Davidson , Pascal Dollé , Stylianos E Antonarakis , Marie-Laure Yaspo , Salvador Martinez , Richard A Baldock , Gregor Eichele , Andrea Ballabio |
2011-01-18 | - |
| 18950867 |
Mol. Immunol. Tanja Scheikl , Bernhard Reis , Klaus Pfeffer , Bernhard Holzmann , Sandra Beer |
2009-02-01 |
Hes1,
Hes5,
Rbpj,
Sash3
|
| 19604361 |
BMC Immunol. Bernhard Reis , Klaus Pfeffer , Sandra Beer-Hammer |
2009-01-01 |
Sash3
|
| 16227612 |
Impaired immune responses and prolonged allograft survival in Sly1 mutant mice. Mol. Cell. Biol. Sandra Beer , Tanja Scheikl , Bernhard Reis , Norbert Hüser , Klaus Pfeffer , Bernhard Holzmann |
2005-11-01 |
Sash3
|
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
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|---|---|---|
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