| Type | Description |
|---|---|
| Definition | CD2-associated protein |
| Date | Results | Publications |
|---|---|---|
| 2019-08-24 12:20:00 | Study identified a homozygous frameshift mutation in CD2AP (p.S198fs) in three siblings born of consanguineous parents who developed childhood-onset focal segmental glomerulosclerosis (FSGS) and end stage renal disease. When the same mutation was introduced in mice by gene editing, the mice developed FSGS and kidney failure. These results provide conclusive evidence that homozygous mutation of CD2AP causes FSGS in humans. | 30612599 |
| 2019-05-18 10:54:00 | The data suggest that inhibition of the catalytic activity of SHIP2 is beneficial in reducing oxidative stress, but leads to deleterious increase in apoptosis in podocytes with reduced expression of CD2AP. | 28878342 |
| 2019-03-30 12:10:00 | CD2AP is indicated as a protein up-regulated by HCV infection, which, in turn, stimulates HCV propagation and steatosis by disrupting insulin signaling; targeting CD2AP may offer an opportunity for alleviating HCV infection and its associated liver pathology | 29729186 |
| 2019-03-16 12:28:00 | We used the HIM technology to investigate at nanometer scale resolution the ultrastructural alterations of the glomerular filtration apparatus in mice lacking the critical slit diaphragm-associated protein CD2AP, highlighting the great potential of HIM to provide new insights into the biology and (patho)physiology of glomerular diseases. | 28814739 |
| 2017-11-18 13:35:00 | Ang II induces the relocalization and reduction of CD2AP via AT1R, which would cause podocyte apoptosis by the suppression of CD2AP/PI3-K signaling | 27590856 |
| Type | IDs |
|---|---|
| Synonymous | AL024079, C78928, METS-1, Mets1 |
| Gene |
UniProtKB-ID:
CD2AP_MOUSE
UniprotKB:
Q9JLQ0
UniParc:
UPI0000215C34
EMBL:
BC019744,
AF077003,
AC111082,
AF149092,
AJ459109
Ensembl:
ENSMUSG00000061665
KO:
mmu:12488
|
| Nucleutide sequences |
EMBL-CDS:
AAF73150.1,
CAD30510.1,
AAC36099.1,
AAH19744.1
Ensembl_TRS:
ENSMUST00000024709
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000024709
RefSeq:
XP_011244566.1,
XP_011244565.1,
NP_033977.3
|
| Others |
UniRef100:
UniRef100_Q9JLQ0
UniRef90:
UniRef90_F1LRS8
UniRef50:
UniRef50_F1LRS8
UniGene:
Mm.218637
CCDS:
CCDS50114.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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