Global analysis of protein localization in budding yeast.
[No authors listed]
摘要
A fundamental goal of cell biology is to define the functions of proteins in the context of compartments that organize them in the cellular environment. Here we describe the construction and analysis of a collection of yeast strains expressing full-length, chromosomally tagged green fluorescent protein fusion proteins. We classify these proteins, representing 75% of the yeast proteome, into 22 distinct subcellular localization categories, and provide localization information for 70% of previously unlocalized proteins. Analysis of this high-resolution, high-coverage localization data set in the context of transcriptional, genetic, and protein-protein interaction data helps reveal the logic of transcriptional co-regulation, and provides a comprehensive view of interactions within and between organelles in eukaryotic cells.
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基因功能
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基因
CHA1, MRC1, PRD1, PEX34, KAR4, APA1, EMC1, MGR1, GLK1, GID7, GRX1, RRP7, HIS4, HBN1, FRM2, LDB16, YCP4, YCR016W, SRD1, RBK1, YCR043C, BUD23, YCR051W, THR4, CTR86, YIH1, TAH1, YCR061W, BUD31, SOL2, PTC6, AHC2, YCR087C-A, YCR090C, MSH3, OCA4, COS4, SWP82, EMP47, RGD2, OTU1, RIM15, BUD27, GNA1, HSP12, IES1, WWM1, SPB4, YFR006W, MIC19, GSY1, YFR016C, IGD1, LSB3, HIS2, RPL29, ERJ5, DUG1, CNN1, BNA6, HXK1, VPS13, RIX7, YLL032C, FRA1, POM33, HIF1, EMC6, YEH1, DRS1, LMO1, RTT109, MHT1, YCT1, FRE6, FPS1, YLR001C, CMS1, LOT6, PML1, SDO1, IZH3, UBR2, PDC1, YLR050C, FCF2, IES3, ERG3, FRS1, BMT6, PER33, FYV7, LAM6, RFU1, SRL2, XDJ1, GEP5, GIS3, REX3, YLR108C, AVL9, YLR118C, YLR126C, USB1, CKI1, PDC5, TIS11, DPH6, RMP1, SPE4, RNH203, UPS2, DPH5, RFX1, YLR177W, YLR179C, SAM1, VTA1, TOS4, SKG3, ATG26, UPS1, PWP1, PBA1, COQ9, MSS51, QRI5, CLB4, ATG38, CDC123, CPR6, COA4, RSA3, IFH1, YLR225C, BUR2, BNA5, LIP2, CDD1, IRC20, RCK2, SSP120, MCP2, NDL1, YLR257W, GSY2, TMA7, DCS1, CMG1, YLR278C, YLR281C, YLR283W, NNT1, YLR287C, GUF1, COQ11, SEC72, YLR297W, NKP2, TAD3, PEX30, TMA10, NMA1, GAS2, YLR345W, CIS1, ORM2, NIT3, ATG33, NMD4, YLR363W-A, GRX8, STP3, PSY3, SWC7, REH1, CCW14, ART10, DUS3, BLS1, UTP21, VIP1, BER1, PUN1, YLR419W, URA4, DCK1, SPP382, MAG2, IMD3, TSR2, ECM30, CAR2, SEC39, PDP3, RBG1, GIP4, SAW1, FUN30, PSK1, CYS3, SWC3, FUN14, BDH2, BDH1, ECM1, GPB2, FLC2, AIM2, ADE1, WHI4, DTD1, NOP6, YDL211C, HEM3, RTN2, TRM8, ASF2, ARF1, UFD2, RBS1, LRG1, GUD1, PHO13, GYP7, MFG1, PTP1, HO, YDL180W, PAR32, SFA1, NRP1, YDL157C, CMR1, CLB3, LDB17, YDL144C, BPL1, SCM3, ARF2, YDL129W, HNT1, YDL124W, YDL121C, CYK3, IWR1, TRM3, TMA17, NSE4, QRI7, QRI1, DUN1, GET3, BUG1, UBX3, NUR1, YDL085C-A, THI3, RXT3, SYO1, PSA1, PBP4, STP4, SIT4, NPC2, PUS9, SLM3, MRX9, GRX6, NHP10, RMD1, NTH1, RCR2, TRP1, KCS1, GCV1, DAS2, ATG31, SES1, NSI1, MIX14, PST2, ARO3, EHD3, HEM12, VMS1, DET1, EMC10, YDR061W, AIM7, RRG1, RTR2, OCA6, DOS2, FMP16, PAA1, PPH3, TFB5, VPS41, TVP23, RRP1, RLI1, GIS1, MSH6, TVP15, TMS1, ALT2, VBA4, ECM18, ARO1, MTC5, YDR132C, RUB1, MTQ2, DOP1, EKI1, GIR2, HOM2, ACL4, TRM82, CDC37, STB3, UPS3, YDR186C, HST4, REF2, VPS64, GTB1, YDR222W, RTN1, LYS4, YDR239C, VHS1, YDR248C, PAM1, MET32, RKM4, YDR262W, HEL2, CIA1, BSC2, RNH202, PHM6, NSE3, HRQ1, DPL1, HDA2, BFR2, PRO1, GPI11, HNT2, PMT7, RAD34, OMS1, UBX5, IRC3, RQC1, SWR1, SVF1, PAL1, YPS7, YPQ2, TRP4, CNL1, BCP1, ESF1, KEI1, YPR1, DXO1, CTS2, VPS74, SDH6, ARO10, YDR391C, HPT1, URH1, ADE8, DFM1, ARO80, CYM1, GPI19, APT2, YDR444W, GUK1, TOM1, SPP41, RMT2, YDR476C, VPS72, VPS60, IZH1, MZM1, PUF6, PSP1, YDR514C, EMI2, URC2, SPS1, AGE1, SNA2, RBA50, HLR1, APA2, KRE28, PAD1, FDC1, IRC4, MIX23, SEA4, ECM21, BNA4, MRX3, MAP2, KTI11, PRS4, YEL1, CMC2, YBL059W, SHP1, PTC3, YBL055C, TOD6, PIN4, PSY4, URA7, RIB1, SHE1, YBL029W, YBL028C, SCT1, YBL010C, UTP20, ECM15, NTH2, UGA2, IPP1, GRX7, YPK3, RKM3, CST26, ZTA1, FMP23, RFS1, YRO2, YBR056W, MUM2, AKL1, ECM2, NRG2, YBR071W, SLM4, YBR085C-A, YBR090C, PBY1, RXT2, YBR096W, YSA1, LYS2, TKL2, PTC4, OPY1, CKS1, YBR138C, YBR139W, BMT2, ADH5, TBS1, APD1, CSH1, TOS1, YSY6, EXO5, TYR1, SSE2, SEC66, SMY2, ECM31, GDT1, PGI1, YBR197C, KTR3, FTH1, DUR1,2, NGR1, SDS24, HPC2, YBP1, OM14, SWC5, PBP2, PRP5, YBR238C, ERT1, YBR241C, YBR242W, GPX2, ARO4, DUT1, MTC4, SHG1, TAE1, MIC12, YPT10, TSC10, REI1, SDH8, EFM2, HSM3, UBX7, DUG2, YBR287W, COS2, GUS1, ADE5,7, TAN1, EMC4, VID30, MTC3, ADH4, RMR1, EDC1, NIF3, FRA2, MDM34, NCS6, ARO8, MDS3, YGL185C, STR3, MPT5, SAE2, XRN1, SUA5, ARI1, ARO2, HUL5, SNT2, SOH1, SCS3, NSA1, CUE3, RMD9, YGL101W, PAN2, LCL3, SCY1, YGL082W, MPC1, KXD1, MNP1, YBP2, PKP2, GEP7, SDS23, ALG13, HEM2, YGL039W, YGL036W, TRP5, GET1, ATE1, PUF4, MPO1, RPN14, EFM5, SWC4, CUL3, ECT1, YGR015C, YGR017W, YGR021W, THG1, IMO32, TIM21, ACB1, ORM1, NQM1, TAM41, SCM4, PEF1, ADE6, ENV11, SLX9, PIL1, PDC6, CTT1, UTP22, DRN1, ASK10, GTF1, VOA1, CLB1, YGR111W, YGR117C, YGR122W, ASN2, YGR125W, YGR126W, YGR130C, LSB1, CCM1, CYS4, PTI1, CHO2, NSR1, RTS3, RBG2, ATF2, PBP1, HGH1, XKS1, YPP1, YCH1, ADE3, TDA10, MVB12, CIR1, SER2, YGR210C, PHO81, YHB1, MIC26, YGR237C, MPC3, CPD1, SOL4, YGR250C, NOP19, BUD32, SAY1, FOL2, YTA7, SLH1, EFG1, RTT102, YGR283C, BIO2, COS6, LAA1, ECM25, ACO2, REE1, UBP12, JJJ2, FMP33, FBP26, INO1, MRX5, IDS2, YJL144W, GLG2, AIM23, SPT10, MTC1, ALB1, PAM16, CHS6, PHS1, BCK1, ALY2, IML2, PRY1, YJL070C, UTP18, DLS1, COA3, BNA3, BIT61, YJL055W, RTT101, GYP6, YJL043W, TAD2, YJL016W, NOP9, MRX12, MHO1, MET3, TMA22, YJR015W, MDE1, RAD26, URB2, UTR1, KCH1, HIT1, YJR056C, NTA1, YAE1, HAM1, LIA1, NPA3, AIM24, EAF6, EMC2, YJR096W, JJJ3, YJR098C, ADO1, YMR1, YJR111C, ILM1, JHD2, IBA57, RSF2, EFM3, STR2, XPT1, SGM1, TTI2, MET5, IML1, HOM6, HMS2, BAT2, YJR149W, YJR154W, COS5, ADD66, PEX1, MIA40, SDS22, DPH2, SPE1, LOT5, FAS1, PRS1, OXP1, DOA1, TRP3, CBT1, KKQ8, TPK3, YKL162C, ELF1, YKL151C, LTV1, MRP8, PMU1, PRR1, RAD27, YJU2, BUD2, CAB3, SRX1, YKL077W, YKL075C, YKL071W, YKL069W, YET1, YKL063C, BLI1, TMA19, MDM35, ELM1, ANR2, DCW1, UGP1, TTI1, TCD2, PAN3, YKL023W, YKL018C-A, URB1, MRT4, MET14, MEH1, YKR011C, PRY2, MIC60, YKR018C, ALY1, NTR2, YKR023W, BCH2, KAE1, YKR041W, SHB17, FMP46, UTP30, OAF3, GPT2, YKR070W, DRE2, YKR075C, ECM4, MSA2, YKR078W, TRZ1, HBS1, OMA1, TVP38, TGL4, PXL1, ESL2, SKG1, RTC1, BSC6, VPS68, TRM13, TRM11, YOL159C-A, ZPS1, RIB4, PPM2, MDY2, YOL107W, SDD3, WRS1, TRM10, YPQ1, MSH2, DUF1, PHM7, IRA2, REX4, SDH5, NBA1, RIB2, PRS5, MAM3, YOL057W, GPM3, PSH1, DDR2, SPE2, RRT8, LDS2, PSK2, NGL1, OPI10, MDM38, TSR4, YOL019W, CMK2, CSI2, UTP23, TSR3, SGT2, YOR022C, CYC2, CUE5, IRC23, ETT1, TMC1, SLD7, YOR062C, SGO1, RTS2, TGL5, WHI5, TCB1, ECM3, RKI1, RGS2, CEX1, RTC5, GCY1, ADE2, AFI1, YOR131C, RUP1, THI80, ELG1, MDM32, NFI1, YRR1, DDP1, GET4, SEY1, YRM1, DCS2, ALE1, SYC1, SER1, TUF1, IES4, LIP5, GEP3, AIM41, RUD3, RCN2, HER1, MCP1, DFR1, YOR238W, PUS7, ENV9, SRL1, TUM1, TMA16, SEC63, HNT3, GPN2, DSE3, RBL2, HRK1, FSF1, RIM20, CAF20, YOR283W, HUA2, RDL1, RDL2, MPD1, YOR289W, YOR292C, YOR296W, BUD7, BIL1, RRG7, SLY41, SFG1, LDB19, PRO2, ALA1, YOR342C, PYK2, MNE1, TFB6, SOG2, MSC6, GDS1, PDE2, GPB1, YOR385W, PHR1, VTH1, IMA3, YIL161W, AIM20, COA1, IMP2', PAN6, TMA108, VHS2, CSM2, ASG1, MET18, RRT14, HIS5, HPM1, YIL108W, SLM1, DPH1, FYV10, BMT5, YIL092W, UTP25, ICE2, AIM19, YIL077C, SER33, YIL067C, EFM4, RGI2, VHR1, GPP1, NEO1, PIG2, AGE2, GVP36, APQ12, TED1, EMC5, HIS6, FAF1, VID28, URM1, YIL001W, AIM21, EGH1, YIR014W, MET28, MRS1, INA22, YVH1, YIR035C, IRC24, YML108W, URA5, CUE4, YML096W, UFO1, YML082W, TDA9, DUS1, YML079W, COS3, YML131W, MSC1, ERG13, PGA3, NAB6, DAT1, BUL2, DAK1, NTE1, HUG1, SML1, CMP2, IMD4, YML053C, VPS71, YMD8, YML037C, AMD1, RCF1, APT1, YML018C, PSP2, TRM9, UBX2, RAD33, YML007C-A, TRM12, GLO1, MIX17, AIM34, ADI1, YMR010W, BUD22, ERG5, SOK2, YMR027W, EIS1, MIH1, SUB1, CSM3, ERB1, FAR3, AEP1, SOV1, UBX4, NAT4, MOT3, TVP18, IRC21, SDD2, RCO1, YMR090W, NPL6, SNO1, ATP25, YMR099C, HFD1, YMR111C, FOL3, YMR114C, MGR3, YMR122W-A, JLP2, ERG29, GID8, CIN4, RIM11, YMR144W, AIM36, YMR160W, HLJ1, INP2, PAH1, MLH1, EAR1, DDR48, PAI3, ECM5, YMR178W, SPT21, ADD37, HSC82, GYL1, ICY1, YMR196W, ROT1, INP1, HFA1, ERG12, ERG8, YMR221C, FSH2, YMR226C, TRI1, RNH1, BCH1, DFG5, COA6, GAD1, HOR7, YMR252C, YMR253C, ROY1, TRM732, TMA23, URA10, SCS7, PRM15, GPI12, RIT1, ABZ2, TDA1, HER2, YMR295C, PRC1, ADE4, ADH2, UBP15, YMR310C, GLC8, YMR315W, COS1, PFA3, PHA2, EMW1, ZIM17, STB1, BXI1, TRF5, HCH1, ERG24, GOR1, IST1, PDR17, GIS2, RTC4, YNL247W, VPS75, ZWF1, LAP3, YNL234W, JJJ1, SQS1, ADE12, MGS1, YNL217W, IES2, VID27, MRX7, RTT106, PSY2, YNL200C, DUG3, YNL181W, RHO5, TDA7, FMP41, YNL162W-A, IGO1, NSG2, CUZ1, INN1, PGA2, YNL146W, AAH1, EAF7, FPR1, YNL134C, FYV6, KRE33, NRK1, ESBP6, NMA111, YNL122C, NCS2, DMA2, YNL115C, DBP2, YNL108C, YAF9, LEU4, MIC27, OCA1, NST1, SNN1, MKT1, PMS1, APJ1, MLF3, LAT1, MTQ1, NOP2, YNL058C, OCA2, MSG5, YNL046W, LAP2, BOP3, YNL040W, NCE103, YNL035C, SIW14, EFM6, PBI2, YNL010W, DOM34, SWM2, ATG3, NRM1, URK1, YNR014W, SMM1, RCF2, YNR021W, MPP6, BUD17, CPR8, YNR029C, ALG12, PPG1, ABZ1, SOL1, EGO4, ZRG17, YNR040W, MVD1, TRM112, FPK1, LYS9, BRE5, ESF2, YNR061C, COS10, YPL247C, RBD2, YPL245W, HSP82, YAR1, ENV7, FAS2, SAM4, KEL3, YPL260W, YPL229W, NEW1, YPL225W, GRE1, FMP40, FLC1, THI6, NIP7, RKM1, TYW1, YPL199C, YPL191C, MRN1, RTT10, TCO89, PPQ1, MRX4, ATG29, SVS1, YPL162C, BEM4, AIM44, KES1, POC4, FRK1, GIP3, RDS2, DBP1, IDI1, HOS3, CAR1, GDE1, YPL109C, YPL108W, YPL107W, SSE1, SYH1, SEC62, GLR1, GPI2, YPL071C, MUK1, BTS1, YPL068C, YPL067C, RGL1, LGE1, SGF11, NOP4, SVL3, TRM44, ERG10, SKS1, RMI1, IRC15, RQC2, NCR1, AEP3, LSP1, PDH1, YPR003C, AIM45, SDD4, NTO1, GLN1, TIP41, PUF2, THP3, ARO7, JID1, FCY1, YPR063C, UBA3, SPE3, LTP1, OPY2, GRS2, NVJ2, YPR098C, DBF20, YPR114W, RGC1, RRG8, MRI1, YLH47, YPR127W, SCD6, NAT3, TAZ1, KAR3, RRP15, ASN1, YPR147C, YPR148C, URN1, PIN3, NCA2, GPH1, JIP5, YPR172W, HDA3, AOS1, GDB1, EFM1, GUT1, ECM29, OCA5, AIM17, YHL018W, YHL017W, YLF2, OTU2, PRS3, YHL008C, LAG1, QCR10, TCD1, DIA4, PIH1, MSC7, BCD1, DOG2, YHR045W, INM1, AAP1, FSH1, FYV4, PAN5, HTD2, DYS1, TRM5, IPI1, RTC3, YHR097C, KIC1, SBE22, GRE3, YPT35, UBA4, YHR112C, APE4, COX23, LSM12, CIA2, EPT1, YHR131C, ECM14, IGO2, SPL2, ARO9, DCD1, RTT107, LAM1, TDA11, MPC2, SOL3, OYE2, SVP26, YHR182W, KOG1, PTH1, ERG9, LNP1, MDM31, AIM18, AIM46, YHR202W, SCH9, SET5, PHO12, IMD2, HPA3, PCM1, MAK10, AFG1, TCA17, IES6, YEL043W, UTR4, YEL025C, MMS21, EAF5, GLC3, MIT1, YEA6, VAB2, IRC22, PMI40, FMP52, YND1, TMA20, YAT2, CHZ1, FIR1, ZRG8, YER034W, EDC2, ARB1, PHM8, KRE29, MXR1, SAH1, SAP1, ISD11, TPA1, HOM3, YER053C-A, CEM1, GPP2, THO1, VHR2, RGI1, TDA2, MRX1, ICP55, YER079W, AIM9, SER3, GET2, ILV1, DOT6, PTC2, TRP2, MET6, IES5, UBP9, PRS2, AST2, RTT105, TMN3, DSE1, SAK1, PMD1, YER134C, RTR1, YER152C, YER156C, GCG1, BCK2, FMP10
原始数据
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文献解读
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