| Type | Description |
|---|---|
| Definition | NAD-dependent histone deacetylase HST4 |
| Date | Results | Publications |
|---|---|---|
| 2017-05-27 11:16:00 | This pathway is functionally relevant to TORC1 signaling since the stress sensitivity of a nonessential TORC1 mutant (tco89Delta) to hydroxyurea and arsenic can be reversed by combining tco89Delta with either hst3Delta, hst4Delta, or sit4Delta Surprisingly, while hst3Delta or hst4Delta rescues the sensitivity tco89Delta has to low concentrations of the TORC1 inhibitor rapamycin, sit4Delta fails to do so | 27343235 |
| 2016-04-23 10:16:00 | Hst4p plays a pivotal role in biotin metabolism and cellular energy homeostasis, and data supports that Hst4p is a functional yeast homologue of the sirtuin deacetylase SIRT3. | 26158509 |
| 2011-10-01 12:09:00 | Our results suggest that Hst3 and Hst4 regulate replicative lifespan through their ability to deacetylate histone H3-K56 to minimize genomic instability. | 21401809 |
| 2010-01-21 00:00:00 | HST3 HST4 play critical roles in maintaining the hypoacetylated state of lysine56 on histone H3 within silent chromatin. | 18799617 |
| 2010-01-21 00:00:00 | Specific functions were found for HST4. | 17446861 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
HST4_YEAST
UniprotKB:
P53688
UniParc:
UPI000012CDAE
EMBL:
Z48784,
AY557699,
BK006938
EnsemblGenome:
YDR191W
KO:
sce:YDR191W
|
| Nucleutide sequences |
EMBL-CDS:
CAA88705.1,
DAA12034.1,
AAS56025.1
Gene_ORFName:
YD9346.03
EnsemblGenome_TRS:
YDR191W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDR191W
RefSeq:
NP_010477.3
|
| Others |
UniRef100:
UniRef100_P53688
UniRef90:
UniRef90_P53688
UniRef50:
UniRef50_P53688
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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