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856079 ERG10

856079

ERG10

acetyl-CoA C-acetyltransferase

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition acetyl-CoA C-acetyltransferase

研究结论

Date Results Publications
2019-02-02 11:27:00 Crystal structures of apo ERG10 and its Cys91Ala variant were solved at resolutions of 2.2 and 1.95 A, respectively. ERG10 shares the characteristic thiolase superfamily fold, with a similar active-site architecture to those of type II thiolases and a similar binding pocket, apart from Ala159 at the entrance to the pantetheine-binding cavity, which appears to be a determinant of the poor binding ability of the substrate. 29372902
2018-05-26 11:53:00 Erg10 thiolase from Saccharomyces cerevisiae showed no acetyl-CoA/butyryl-CoA branched condensation activity, but variants at position F293 resulted the most active and selective biocatalysts for this reaction. 29360348

名称对应

Type IDs
Synonymous LPB3, TSM0115
Gene
UniProtKB-ID: THIL_YEAST
UniprotKB: P41338
UniParc: UPI0000136E4F
EMBL: L20428, BK006949, U36624
EnsemblGenome: YPL028W
KO: sce:YPL028W
Nucleutide sequences
EMBL-CDS: AAA62378.1, AAB68159.1, DAA11401.1
Gene_ORFName: LPB3
EnsemblGenome_TRS: YPL028W_mRNA
Protein sequencees
EnsemblGenome_PRO: YPL028W
RefSeq: NP_015297.1
Others
UniRef100: UniRef100_P41338
UniRef90: UniRef90_P41338
UniRef50: UniRef50_P41338

全选

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