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850619 VPS13

850619

VPS13

membrane morphogenesis protein VPS13

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition membrane morphogenesis protein VPS13

研究结论

Date Results Publications
2021-02-20 13:29:00 Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes. 32182622
2020-10-03 12:59:00 Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy. 32690699
2019-09-28 10:52:00 Mcp1 is a mitochondrial adaptor for Vps13, and the Vps13-Mcp1 interaction, but not Ypt35, is required when ER-mitochondria contacts are lost. 30018089
2017-10-07 11:45:00 findings support a model in which Mcp1 and Vps13 work as functional effectors of vacuole-mitochondria contact sites, while tethering is mediated by other factors, including Vps39. 28864540
2017-09-02 10:46:00 his study demonstrates that VPS13 is also important for mitochondrial integrity. Introduction of VPS13A mutations identified in chorea acanthocytosis patients at cognate sites in yeast VPS13 are specifically defective in compensating for the lack of ERMES, suggesting that mitochondrial dysfunction might be the basis for chorea acanthocytosis. 27280386

名称对应

Type IDs
Synonymous SOI1, VPT2
Gene
UniProtKB-ID: VPS13_YEAST
UniprotKB: Q07878
UniParc: UPI0000138B80
EMBL: AF001317, Z73145, BK006945, Z73144
EnsemblGenome: YLL040C
KO: sce:YLL040C
Nucleutide sequences
EMBL-CDS: CAA97491.1, AAC08284.1, DAA09282.1, CAA97490.1
EnsemblGenome_TRS: YLL040C_mRNA
Protein sequencees
EnsemblGenome_PRO: YLL040C
RefSeq: NP_013060.1
Others
UniRef100: UniRef100_Q07878
UniRef90: UniRef90_Q07878
UniRef50: UniRef50_Q07878

全选

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研究热度

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