| Type | Description |
|---|---|
| Definition | ribonucleotide reductase inhibiting protein SML1 |
| Date | Results | Publications |
|---|---|---|
| 2017-07-15 10:57:00 | We also present evidence that indicates Rim11/Ume6 works independently but in parallel with that of checkpoint inhibition, dNTP regulation, and sister-chromatid recombination. In conclusion, our results establish Rim11, Ume6, the histone deacetylase complex Sin3-Rpd3 and Sml1 as new factors important in the events of faulty lagging strand synthesis. | 28468907 |
| 2017-04-29 12:09:00 | Multiple turnover kinetics show that Sml1 inhibition of dGTP/ADP- and ATP/CDP-bound ScRR follows a mixed inhibition mechanism. However, Sml1 cooperatively binds to the ES complex in the dGTP/ADP form, whereas with ATP/CDP, Sml1 binds weakly and noncooperatively | 27155231 |
| 2015-02-14 10:04:00 | levels of the Sml1 protein specifically decrease in response to both nutritional and genetic Fe deficiencies in a Dun1-dependent but Mec1/Rad53- and Aft1-independent manner | 24958100 |
| 2013-09-14 11:42:00 | curcumin induces degradation of Sml1p, a ribonucleotide reductase inhibitor involved in regulating dNTPs production. | 23520547 |
| 2010-01-21 00:00:00 | The amino(N)-terminal domain protects the carboxyl-terminal domain of Sml1 from degradation and may explain why the N-terminal region has been conserved in evolution. | 19086274 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SML1_YEAST
UniprotKB:
Q04964
UniParc:
UPI000013B9AE
EMBL:
AY557961,
Z46729,
BK006946
EnsemblGenome:
YML058W
KO:
sce:YML058W
|
| Nucleutide sequences |
EMBL-CDS:
AAS56287.1,
CAA86717.1,
DAA09840.1
Gene_ORFName:
YM9958.04
EnsemblGenome_TRS:
YML058W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YML058W
RefSeq:
NP_013653.1
|
| Others |
UniRef100:
UniRef100_Q04964
UniRef90:
UniRef90_Q04964
UniRef50:
UniRef50_Q04964
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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