| Type | Description |
|---|---|
| Definition | SUMO ligase MMS21 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:48:00 | A natural variant of the essential host gene MMS21 restricts the parasitic 2-micron plasmid in Saccharomyces cerevisiae. | 33063663 |
| 2020-02-22 10:37:00 | Pol2 is the main target of SUMOylation within the replisome and its modification requires the SUMO-ligase Mms21, a subunit of the Smc5/6 complex | 31765407 |
| 2019-02-23 13:08:00 | These results reveal a mechanism to enhance a SUMO E3 ligase activity by direct DNA binding and to restrict sumoylation in the vicinity of those Smc5/6-Nse2 molecules engaged on DNA. | 29769404 |
| 2018-07-14 10:35:00 | Mms21 prevents the accumulation of spontaneous DNA lesions that cause diverse gross chromosomal rearrangements. | 29505562 |
| 2018-04-07 11:40:00 | Our findings reveal a requirement for the Smc5/6 complex, including Mms21/Nse2 mediated sumoylation, and topoisomerase-1 (Top1), for maintaining stability of a chromosome having low origin density and suggest a functional cooperation between the Smc5/6 complex and Top1 in maintenance of topologically challenged chromosomes prone to replication fork collapse or accumulation of torsional stress | 28204881 |
| Type | IDs |
|---|---|
| Synonymous | NSE2, PSO10 |
| Gene |
UniProtKB-ID:
NSE2_YEAST
UniprotKB:
P38632
UniParc:
UPI0000168309
EMBL:
U18530,
U12311,
BK006939,
AY558441
EnsemblGenome:
YEL019C
KO:
sce:YEL019C
|
| Nucleutide sequences |
EMBL-CDS:
AAA20471.1,
AAB64496.1,
AAS56767.1,
DAA07634.1
EnsemblGenome_TRS:
YEL019C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YEL019C
RefSeq:
NP_010896.3
|
| Others |
UniRef100:
UniRef100_P38632
UniRef90:
UniRef90_P38632
UniRef50:
UniRef50_P38632
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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