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851551 GRX6

851551

GRX6

glutathione-disulfide reductase GRX6

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition glutathione-disulfide reductase GRX6

研究结论

Date Results Publications
2017-11-26 01:48:00 Crystal structure of Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster has been presented. 27710937
2015-08-22 10:06:00 A specific function influenced by Grx6 activity is the homeostasis of intracellular calcium. Grx6-deficient mutants have reduced levels of calcium in the ER lumen, whereas accumulation occurs at the cytosol from extracellular sources. 25355945
2010-05-10 11:08:00 Compared to the classic dithiol glutaredoxin Grx1, Grx6 has a lower glutathione disulfide reductase activity but a higher glutathione S-transferase activity. 20347849
2010-01-21 00:00:00 Grx6 and Grx7 do not play a general role in the oxidative folding of proteins in the early secretory pathway but rather counteract the oxidation of specific thiol groups in substrate proteins. 18400945
2010-01-21 00:00:00 S. pombe cells harboring plasmid pFGRX6 containing the Grx6 gene had about 1.3-fold elevated Grx activity in the exponential phase, and grew better than the control cells under some stressful conditions. 18182845

名称对应

Type IDs
Gene
UniProtKB-ID: GLRX6_YEAST
UniprotKB: Q12438
UniParc: UPI0000036C2D
EMBL: Z48432, BK006938, Z74059
EnsemblGenome: YDL010W
KO: sce:YDL010W
Nucleutide sequences
EMBL-CDS: CAA98567.1, DAA11838.1, CAA88349.1
Gene_ORFName: D2890
EnsemblGenome_TRS: YDL010W_mRNA
Protein sequencees
EnsemblGenome_PRO: YDL010W
RefSeq: NP_010274.1
Others
UniRef100: UniRef100_Q12438
UniRef90: UniRef90_Q12438
UniRef50: UniRef50_Q12438

全选

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