| Type | Description |
|---|---|
| Definition | mismatch repair ATPase MLH1 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 14:20:00 | Results provide evidence that the MLH1 gene encoding one of the crucial components of the mismatch repair, is required for transcriptional repression at silent mating-type loci and telomeres. | 32469861 |
| 2019-11-30 12:03:00 | Experiments were performed in an MMR-proficient strain, a strain with compromised mismatch-recognition activity (msh6Delta) and a strain that retained mismatch-recognition activity but was unable to process mismatches (mlh1Delta). | 30809658 |
| 2019-08-31 11:31:00 | Mlh1-Pms1 complexes with shorter IDRs that disrupt MMR retain wild-type DNA binding affinity but are impaired for diffusion on both naked and nucleosome-coated DNA. Moreover, the IDRs also regulate the adenosine triphosphate hydrolysis and nuclease activities that are encoded in the structured N- and C-terminal domains of the complex | 30541127 |
| 2019-03-02 11:32:00 | Genotyping analysis indicated that MLH1-PMS1 incompatibility was the major driver of mutation rate in the isolates. The variation in the mutation rate of incompatible spore clones could be due to background suppressors and enhancers, as well as aneuploidy seen in the spore clones. | 30348651 |
| 2018-02-10 11:31:00 | Here the authors show that the budding yeast mismatch repair related MutLbeta complex, Mlh1-Mlh2, specifically interacts with the conserved meiotic Mer3 helicase, which recruits it to recombination hotspots, independently of mismatch recognition. | 28051769 |
| Type | IDs |
|---|---|
| Synonymous | PMS2 |
| Gene |
UniProtKB-ID:
MLH1_YEAST
UniprotKB:
P38920
UniParc:
UPI00000531C8
EMBL:
DQ356646,
DQ356636,
BK006946,
DQ356633,
DQ356637,
DQ356644,
DQ356643,
DQ356639,
DQ356645,
DQ356635,
Z49705,
DQ356641,
DQ356634,
DQ356640,
U07187,
DQ356638,
DQ356642
EnsemblGenome:
YMR167W
KO:
sce:YMR167W
|
| Nucleutide sequences |
EMBL-CDS:
AAA16835.1,
ABC86947.1,
ABC86941.1,
ABC86938.1,
ABC86937.1,
ABC86944.1,
DAA10063.1,
ABC86949.1,
CAA89803.1,
ABC86942.1,
ABC86940.1,
ABC86943.1,
ABC86939.1,
ABC86946.1,
ABC86945.1,
ABC86948.1,
ABC86950.1
Gene_ORFName:
YM8520.16
EnsemblGenome_TRS:
YMR167W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YMR167W
RefSeq:
NP_013890.1
|
| Others |
UniRef100:
UniRef100_P38920
UniRef90:
UniRef90_P38920
UniRef50:
UniRef50_P38920
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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