| Type | Description |
|---|---|
| Definition | ATP-dependent 3'-5' DNA helicase |
| Date | Results | Publications |
|---|---|---|
| 2019-12-28 10:51:00 | Pif1DeltaN was still able to synergize with the Hrq1 helicase to inhibit telomerase activity in vitro, similar to full-length Pif1. These data impact our understanding of Pif1 helicase evolution and the roles of these enzymes in the maintenance of genome integrity. | 31142053 |
| 2019-04-13 11:42:00 | results suggest that Hrq1 and Pif1 interact and that their concerted activities ensure proper telomere length homeostasis in vivo | 30068549 |
| 2017-06-24 10:44:00 | These results establish the importance of DNA sequence in Hrq1 helicase activity, and the absence of Hrq1 strand annealing activity explains the previously identified discrepancies between S. cerevisiae Hrq1 and human RecQ4. | 28385527 |
| 2014-11-22 13:01:00 | Overexpression of Hrq1K318A helicase-deficient protein rendered mutant cells more sensitive to 4-nitroquinoline-1-oxide and cisplatin, suggesting that helicase activity is required for the proper function of Hrq1 in nucleotide excision repair. | 24682993 |
| 2014-09-27 11:28:00 | Hrq1 acts catalytically to protect against DNA interstrand crosslinks and affects telomere length by a noncatalytic mechanism. | 24440721 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
HRQ1_YEAST
UniprotKB:
Q05549
UniParc:
UPI0000069D93
EMBL:
BK006938,
U51031
EnsemblGenome:
YDR291W
KO:
sce:YDR291W
|
| Nucleutide sequences |
EMBL-CDS:
AAB64466.1,
DAA12130.1
EnsemblGenome_TRS:
YDR291W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDR291W
RefSeq:
NP_010577.3
|
| Others |
UniRef100:
UniRef100_Q05549
UniRef90:
UniRef90_Q05549
UniRef50:
UniRef50_Q05549
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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