| Type | Description |
|---|---|
| Definition | ssDNA endodeoxyribonuclease SAE2 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-30 13:11:00 | sae2-ms mutant upregulates Mre11-Rad50-Xrs2 complex and Tel1 signaling activities at DSBs by reducing Mre11 endonuclease activity. | 30538107 |
| 2019-03-30 10:05:00 | Overexpression of the RNA-DNA helicase Senataxin suppresses DNA damage sensitivity and R-loop accumulation in Sae2/CtIP-deficient cells, and a catalytic mutant of CtIP fails to complement this sensitivity, indicating a role for CtIP nuclease activity in the repair process. | 30523780 |
| 2019-01-12 11:00:00 | Phosphorylation of S. cerevisiae ssDNA endodeoxyribonuclease SAE2 controls its capacity to promote the Mre11-Rad50-Xrs2 (MRX) nuclease to initiate resection of blocked DNA ends. DNA damage and cell cycle-dependent phosphorylation leads to Sae2 tetramerization. Phosphorylation of the conserved C-terminal domain of Sae2 is a prerequisite for its interaction with the MRX subunit Rad50. | 30275497 |
| 2018-02-10 11:46:00 | MRX-Sae2 efficiently cleaves near Ku-blocked DNA ends, which shows how recombination competes with NHEJ in the S/G2 phase when Sae2 is phosphorylated and thus capable of promoting endonucleolytic DNA cleavage by MRX | 29321179 |
| 2017-12-09 13:34:00 | Authors find that the ability of Sae2 to promote MRX nuclease functions is important for DNA damage survival, particularly in the absence of Dna2 nuclease activity. | 28970327 |
| Type | IDs |
|---|---|
| Synonymous | COM1 |
| Gene |
UniProtKB-ID:
COM1_YEAST
UniprotKB:
P46946
UniParc:
UPI00001354DE
EMBL:
X84705,
U49447,
BK006941,
Z72697
EnsemblGenome:
YGL175C
KO:
sce:YGL175C
|
| Nucleutide sequences |
EMBL-CDS:
CAA96887.1,
DAA07938.1,
AAB96338.1,
CAA59178.1
Gene_ORFName:
G1639
EnsemblGenome_TRS:
YGL175C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YGL175C
RefSeq:
NP_011340.1
|
| Others |
UniRef100:
UniRef100_P46946
UniRef90:
UniRef90_P46946
UniRef50:
UniRef50_P46946
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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