| Type | Description |
|---|---|
| Definition | aminopeptidase |
| Date | Results | Publications |
|---|---|---|
| 2019-10-19 11:38:00 | Data report the crystal structures of Icp55 including one bound to the apstatin inhibitor. Apart from icp activity, the enzyme was found to exhibit Xaa-Pro aminopeptidase activity in vitro. Furthermore, the enzyme seems to exist in a rapid equilibrium between monomers and dimers. The latter was found to be the active species with loop dynamics at the dimer interface playing an important role in activity. | 30582634 |
| 2014-06-21 10:17:00 | The icp55 deletion strain demonstrated an increased chronological lifespan and decreased reactive oxygen species. | 24116217 |
| 2014-04-12 11:48:00 | A novel substrate, Isa2, is likely processed by Icp55 in two consecutive steps and thus might represent the first example of a triple processing event in a mitochondrial precursor protein. | 23964590 |
| 2010-01-21 00:00:00 | Icp55 protease and its substrate Nfs1 appear to be dual distributed between the nucleus and mitochondria | 19720832 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
ICP55_YEAST
UniprotKB:
P40051
UniParc:
UPI000013ACAC
EMBL:
BK006939,
U18839
EnsemblGenome:
YER078C
KO:
sce:YER078C
|
| Nucleutide sequences |
EMBL-CDS:
AAB64633.1,
DAA07738.1
EnsemblGenome_TRS:
YER078C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YER078C
RefSeq:
NP_011001.1
|
| Others |
UniRef100:
UniRef100_P40051
UniRef90:
UniRef90_P40051
UniRef50:
UniRef50_P40051
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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