| Type | Description |
|---|---|
| Definition | poly(A)-specific ribonuclease |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 10:52:00 | Crystal structures of Saccharomyces cerevisiae Pan2 in complex with RNA show that, surprisingly, Pan2 does not form canonical base-specific contacts. Instead, it recognizes the intrinsic stacked, helical conformation of poly(A) RNA. | 31110294 |
| 2017-04-20 16:25:00 | PAN2 and PAN3 are not required for mRNA poly(A) tail length control during de novo synthesis but may act in conjuction with Pab1p at a later stage in mRNA metabolism. | 15894541 |
| 2014-09-20 11:35:00 | The exonuclease subunit Pan2 does not bind RNA by itself, but binds to an asymmetric Pan3 homodimer via an extensive, high-affinity interaction. | 24872509 |
| 2010-01-21 00:00:00 | Accumulation of polyadenylated mRNAs at sites of transcription occurs in strains lacking the PAN2 or PAN3 subunits of the poly(A) nuclease PAN. PAN is identified as an important factor that couples 3' processing of pre-mRNAs to export. | 15630021 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
PAN2_YEAST
UniprotKB:
P53010
UniParc:
UPI0000131263
EMBL:
BK006941,
U39204,
Z72616
EnsemblGenome:
YGL094C
KO:
sce:YGL094C
|
| Nucleutide sequences |
EMBL-CDS:
CAA96800.1,
DAA08012.1,
AAC49152.1
EnsemblGenome_TRS:
YGL094C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YGL094C
RefSeq:
NP_011421.1
|
| Others |
UniRef100:
UniRef100_P53010
UniRef90:
UniRef90_P53010
UniRef50:
UniRef50_P53010
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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