| Type | Description |
|---|---|
| Definition | type 2A-related serine/threonine-protein phosphatase SIT4 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 12:33:00 | Downregulation of Snf1p suppressed Deltasit4 mutant phenotypes, including mitochondrial derepression, resistance to oxidative stress and increased lifespan. Overall, this indicates a more prominent role of Snf1p downstream the Sit4p signalling pathway than previously suspected. | 31991152 |
| 2019-09-21 12:27:00 | Results show that the multifunctional protein phosphatase Sit4 is required for tRNA modification and modification independent regulatory processes in S. cerevisiae. Absence of Sit4 lowers cellular lipid droplets (LD) levels and results in increased sensitivity to acetyl-CoA carboxylase (Acc1) inhibition by soraphen A. | 29997346 |
| 2018-11-03 11:06:00 | suggest that Sit4p-mediated dephosphorylation of Atp2p-T124/T317 downregulates Atp2p alongside with ATP synthase and mitochondrial function | 29719209 |
| 2018-03-31 10:04:00 | Phytoceramide accumulation and Sit4-dependent signaling mediate the mitochondrial dysfunction and shortened lifespan in the yeast model of Niemann-Pick type C1, in part through modulation of the Pkh1-Sch9 pathway. | 28988886 |
| 2017-05-27 11:16:00 | This pathway is functionally relevant to TORC1 signaling since the stress sensitivity of a nonessential TORC1 mutant (tco89Delta) to hydroxyurea and arsenic can be reversed by combining tco89Delta with either hst3Delta, hst4Delta, or sit4Delta Surprisingly, while hst3Delta or hst4Delta rescues the sensitivity tco89Delta has to low concentrations of the TORC1 inhibitor rapamycin, sit4Delta fails to do so | 27343235 |
| Type | IDs |
|---|---|
| Synonymous | PPH1 |
| Gene |
UniProtKB-ID:
PP11_YEAST
UniprotKB:
P20604
UniParc:
UPI0000052E64
EMBL:
BK006938,
Z71781,
M24395,
Z74095
EnsemblGenome:
YDL047W
KO:
sce:YDL047W
|
| Nucleutide sequences |
EMBL-CDS:
CAA98609.1,
DAA11808.1,
AAA56864.1,
CAA96442.1
Gene_ORFName:
D2693
EnsemblGenome_TRS:
YDL047W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDL047W
RefSeq:
NP_010236.1
|
| Others |
UniRef100:
UniRef100_P20604
UniRef90:
UniRef90_P20604
UniRef50:
UniRef50_P20604
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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