| Type | Description |
|---|---|
| Definition | E3 ubiquitin-protein ligase HEL2 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 12:04:00 | Hel2-dependent polyubiquitination of collided disomes and, preferentially, trisomes. The distinct trisome architecture, visualized using cryo-EM, provides the structural basis for the more-efficient recognition by Hel2 compared with that of disomes. Subsequently, the Slh1 helicase subunit of the trigger complex preferentially dissociates the first stalled polyubiquitinated ribosome in an ATP-dependent manner. | 32203490 |
| 2017-06-10 10:19:00 | premature arrest at ribosome stalling sequences still occurred robustly in the absence of Asc1, Hel2, and Slh1. However, these three factors were required for the ribosome quality control complex to modify the nascent chain. | 28223409 |
| 2016-04-16 10:40:00 | More detailed analyses indicated that the effects of K63R mutants were independent of the proteasome and that K63 polyubiquitination is dependent on Hel2, one of the E3 ligases. | 25909477 |
| 2013-01-26 11:17:00 | The results highlight the importance of posttranslational histone regulatory mechanisms that employ multiple E3 ubiquitin ligases such as Hel2(YDR266C)to ensure excess histone degradation and thus contribute to the maintenance of genomic stability. | 22570702 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
HEL2_YEAST
UniprotKB:
Q05580
UniParc:
UPI000006B81F
EMBL:
U51030,
BK006938
EnsemblGenome:
YDR266C
KO:
sce:YDR266C
|
| Nucleutide sequences |
EMBL-CDS:
DAA12110.1,
AAB64455.1
EnsemblGenome_TRS:
YDR266C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDR266C
RefSeq:
NP_010552.3
|
| Others |
UniRef100:
UniRef100_Q05580
UniRef90:
UniRef90_Q05580
UniRef50:
UniRef50_Q05580
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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